114479-32-2Relevant academic research and scientific papers
MIXED ANHYDRIDES IN PEPTIDE SYNTHESIS. INFLUENCE OF THE SOLVENT AND THE AMINE ON THE RACEMIZATION OF DMet RESIDUE OF AN ENKEPHALIN SEQUENCE.
Torres, J.L.,Haro, I.,Valencia, G.,Anton, J.M. Garcia,Reig, F.
, p. 4031 - 4034 (1987)
A comparative study on the effectiveness of all possible amine/solvent combination with three different solvents (THF, DCM, DMF) and three different bases (NMM, NMPi, NMPo) in avoiding the racemization of the DMet residue during a mixed anhydride coupling has been carried out.The results show that the best combination is THF/NMM.Though, when more polar solvents are required, the system DMF/NMPo is recommended.
