
Tetrahedron p. 4031 - 4034 (1987)
Update date:2022-07-29
Topics:
Torres, J.L.
Haro, I.
Valencia, G.
Anton, J.M. Garcia
Reig, F.
A comparative study on the effectiveness of all possible amine/solvent combination with three different solvents (THF, DCM, DMF) and three different bases (NMM, NMPi, NMPo) in avoiding the racemization of the DMet residue during a mixed anhydride coupling has been carried out.The results show that the best combination is THF/NMM.Though, when more polar solvents are required, the system DMF/NMPo is recommended.
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