114479-96-8Relevant academic research and scientific papers
FunctionaIized erythro N-protected α-amino epoxides. Stereocontrolled synthesis and biological activity
Albeck, Amnon,Estreicher, Gary I.
, p. 5325 - 5338 (1997)
Erythro N-protected α-amino epoxides, derived from α-amino acids bearing functionalized side chains, were synthesized. The key synthetic step is a stereoselective reduction of the corresponding haloketone either to the halohydrin or directly to the epoxid
SIRTUIN INHIBITORS
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Page/Page column 108, (2009/04/25)
This invention relates to compounds and methods for the inhibition of sirtuin enzymatic activity. More particularly, the invention provides for compounds of formula (I), Y__L__Z__D, and N-oxides, hydrates, solvates, pharma
Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors
Manku, Sukhdev,Allan, Martin,Nguyen, Natalie,Ajamian, Alain,Rodrigue, Jacques,Therrien, Eric,Wang, James,Guo, Tim,Rahil, Jubrail,Petschner, Andrea J.,Nicolescu, Alina,Lefebvre, Sylvain,Li, Zuomei,Fournel, Marielle,Besterman, Jeffrey M.,Deziel, Robert,Wahhab, Amal
scheme or table, p. 1866 - 1870 (2009/11/30)
We have recently reported on a novel class of histone deacetylase (HDAC) inhibitors bearing a sulfamide group as the zinc-binding unit. Herein, we report on the synthesis of sulfamide based inhibitors designed around a lysine scaffold and their structure-
SULFAMIDE AND SULFAMATE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS
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Page/Page column 104, (2010/11/29)
This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I), and racemic and scalemic mixtures, diastereomers and enantiomers thereof: or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, prodrug or complex thereof, wherein Y, L, Z, W, M, Ra, Rb and Rc are as defined in the specification.
