FunctionaIized erythro N-protected α-amino epoxides. Stereocontrolled synthesis and biological activity

Article abstract of DOI:10.1016/S0040-4020(97)00195-6

Erythro N-protected α-amino epoxides, derived from α-amino acids bearing functionalized side chains, were synthesized. The key synthetic step is a stereoselective reduction of the corresponding haloketone either to the halohydrin or directly to the epoxid