114483-62-4

Upstream product

• 141-97-9 ethyl acetoacetate 
• 17356-08-0 thiourea 
• 135-02-4 ortho-anisaldehyde 
• 1147550-11-5 ammonium thiocyanate 

Downstream Products

• 219806-95-8 ethyl (RS)-2-(2,6-dichlorophenyl)-5-(2-methoxyphenyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1034918-21-2 6-ethoxycarbonyl-7-methyl-5-(2-methoxyphenyl)-5H-thiazolo[3,2-a]pyrimidine 
• 1019839-75-8 ethyl 4-[2-methoxyphenyl]-3-formyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1426660-92-5 C₃₀H₃₂N₄O₆S 
• 332898-25-6 ethyl 5-(2-methoxyphenyl)-7-methyl-3-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxylate 
• 1445235-42-6 (E)-ethyl 4-(2-methoxyphenyl)-6-methyl-2-(2-oxo-2-phenylethylidene)-3-(thiophene-2-carbonyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1445235-59-5 (E)-ethyl3-benzoyl-4-(2-methoxyphenyl)-6-methyl-2-(2-oxo-2-phenylethylidene)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1445235-51-7 (E)-ethyl3-(furan-2-carbonyl)-4-(2-methoxyphenyl)-6-methyl-2-(2-oxo-2-phenylethylidene)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1445235-44-8 (E)-ethyl 2-(3,3-dimethyl-2-oxobutylidene)-4-(2-methoxyphenyl)-6-methyl-3-(thiophene-2-carbonyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1445235-53-9 C₂₆H₃₀N₂O₆ 
• 1445235-43-7 (E)-ethyl 4-(2-methoxyphenyl)-6-methyl-2-(2-oxoheptylidene)-3-(thiophene-2-carbonyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Relevant academic research and scientific papers

Carbon nanotubes supported by titanium dioxide nanoparticles as recyclable and green catalyst for mild synthesis of dihydropyrimidinones/thiones

The catalytic activity of titanium dioxide supported on carbon nanotubes has been investigated in a one-pot three components condensation reaction (Biginelli reaction). The TiO2-CNT nanocomposites as catalyst are highly stable and completely he

1,3,5-Tris(2-hydroxyethyl)isocyanurate functionalized graphene oxide: A novel and efficient nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1: H)-ones

In this research, the preparation, characterization and catalytic application of a novel 1,3,5-tris(2-hydroxyethyl)isocyanurate functionalized graphene oxide (GO-THEIC) nanomaterial are described. The GO/THEIC nanomaterial was characterized by Fourier tra

Titanium dioxide supported on MWCNTs as an eco-friendly catalyst in the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones accelerated under microwave irradiation

Some transition metal oxides supported on MWCNTs were prepared as novel heterogeneous catalysts using the facile processes. Then, the catalytic behaviour of transition metal oxide-MWCNT nanocomposites was investigated in the Biginelli one-pot cyclocondens

Ionic liquid-assisted synthesis of dihydropyrimidin(thi)one Biginelli adducts and investigation of their mechanism of urease inhibition

Twenty-six Biginelli adducts were synthesized through an ionic liquid-assisted synthesis with up to 92% yield. Sixteen of these Biginelli adducts were then assayed to determine their antiureolytic activity against purified urease from jack beans. The substances BA7-S, BA9-S and BA11-S were shown to be as efficient inhibitors as hydroxyurea, a positive control used in in vitro screening assay against urease. Fluorescence studies revealed that BA7-S, BA9-S, BA11-S and BA5-S possessed high binding constant values of 5.95, 6.72, 4.55, and 4.28 M-1, respectively, while BAS12-S, without substituents, showed a low value of log Kb = 2.16 M-1. In addition, in the most thermodynamically favorable BA5-S and BA7-S urease complexes, the corresponding Biginelli adducts were capable of interacting with the active site of urease through non-ionic interactions, such as hydrophobic interactions, or hydrogen and van der Waals interactions, respectively. In silico studies also supported that the BAs interact with the active site, confirming the fluorescence and kinetic assay studies, which clearly indicate that BA5-S and BA7-S are competitive inhibitors (Ki = 0.96 and 0.57 mM, respectively). In silico studies also showed that the substituents in the aromatic ring interact with Ni atoms to form a stable complex.

UV-Light-Irradiated Trifluoromethylation of Diheteroaryl Disulfides with CF3SO2Na

A simple protocol for the UV light irradiated preparation of heteroaryl trifluoromethyl thioethers from disulfides and inexpensive, environmentally sodium triflinate (CF3SO2Na) has been developed. The features of simple and clean rea

Metal-Free Visible-Light-Mediated Desulfurization and Aromatization of Dihydropyrimidine-2-thiones for Synthesis of 2-Unsubstituted Pyrimidines

The visible-light-mediated aerobic desulfurization and aromatization of Biginelli 3,4-dihydropyrimidine-2(1H)-thiones for a one-step synthesis of 2-unsubstituted pyrimidines was established. The protocol uses molecular oxygen as an inexpensive oxidant, wi

A domino desulfitative coupling and decarboxylative coupling of 3,4-dihydropyrimidine-2-thiones with copper(I) carboxylates

A novel and general carbon-nitrogen and carbon-carbon cross-coupling reaction between 3,4-dihydropyrimidine-2-thiones and copper(I) carboxylates were performed in the presence of palladium acetate. The copper(I) carboxylates act not only as desulfurative

A reactant promoted solvent free synthesis of 3,4-dihydropyrimidin-2(1H)-thione analogues using ammonium thiocyanate

This is the first-time ammonium thiocyanate (NH4SCN) has been used as a self-promoting reactant for the synthesis of 3,4-dihydropyrimidin-2(1H)-thiones. This report describes a greener, efficient and economic protocol for one pot three-component synthesis of Biginelli compounds using various aldehydes, β-ketoesters and ammonium thiocyanate. Ammonium thiocyanate being a weak acid, accelerate the rate of reaction to obtain Biginelli compounds in solvent-free condition at 110?°C. The key advantages of the present method are high yields, short reaction time, solvent free condition, easy workup and ability to tolerate a variety of functional groups. Ammonium thiocyanate is readily available, cheaper, safer and industrial acceptable material which gives economical as well as ecological rewards to the present method.

Sulfated polyborate: a new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction

In this report, an efficient high-yield method for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli reaction with various aldehydes, β-ketoesters/β-diketones and urea/thiourea is described. The reaction was catalyze

Efficient and green catalytic synthesis of dihydropyrimidinone (thione) derivatives using cobalt nitrate in solvent-free conditions

A series of 3,4-dihydropyrimidin-2(1H)-one(thione) derivatives was synthesized using Co(NO3)2.6H2O in solvent-free condition. Avoiding organic solvents during the chemical reactions leading to an economic approach is effective. The reaction is characteriz