1445235-53-9Relevant academic research and scientific papers
A domino desulfitative coupling/acylation/hydration process cocatalyzed by copper(I) and palladium(II): Synthesis of highly substituted and functionalized pyrimidines
Quan, Zheng-Jun,Hu, Wang-Hua,Jia, Xiao-Dong,Zhang, Zhang,Da, Yu-Xia,Wang, Xi-Cun
, p. 2939 - 2948 (2012)
A domino desulfitative coupling/acylation/hydration process to synthesize C-2-(2-oxo-2-phenylethylidene)- and N-3-carbonyl-substituted pyrimidines by unprecedented C-C and C-N cross-coupling reactions is described. This methodology couples 3,4-dihydropyrimidine-2-thiones and alkynes under modified Liebeskind-Srogl conditions using palladium acetate and copper(I) carboxylate. Remarkably the copper(I) carboxylates simultaneously act as desulfitative and acylation reagents in the reaction. Copyright
