114486-35-0

Upstream product

• 5162-44-7 1-bromo-4-butene 
• 81167-39-7 methyl N-(diphenylmethylene)glycinate 

Downstream Products

• 750638-86-9 methyl 2-(tosylamino)hex-5-enoate 
• 188195-01-9 (R)-2-(Acryloyl-benzyl-amino)-hex-5-enoic acid methyl ester 
• 188195-02-0 (R)-2-[Allyl-(4-methoxy-benzyl)-amino]-hex-5-enoic acid methyl ester 
• 103067-78-3 (2R)-2-amino-5-hexenoic acid 
• 195311-23-0 methyl 5-methylpyrrolidine-2-carboxylate 

Relevant academic research and scientific papers

Development of oxidative formylation and ketonylation reactions

The first oxidative formylation and oxidative ketonylation of alkenylamines and alkenyl alcohols is demonstrated. A range of substrates that participate in this process are provided. Oxidative formylation was found to proceed optimally with the use of triphenylsilane as the hydride source. Oxidative ketonylation was feasible with a number of organometallic partners, especially dialkylzinc or organostannanes. An interesting finding regarding the fate of various acylpalladium intermediates is discussed. Georg Thieme Verlag Stuttgart.

Cyclisation of aminyl radicals derived from amino acids

α-Amino acid aminyl radicals have been generated from sulfenamide precursors using Bu3SnH. The aminyl radicals undergo 5-exo-trig cyclisation reactions onto suitably placed N-alkenyl or α-alkenyl chains on the amino acids with reasonable diastereoselectivity. The α-ester of the amino acid imparts electrophilic behaviour to the aminyl radicals and facilitates cyclisation onto alkenes.