114501-07-4

Upstream product

• 114501-02-9 2-(o-methoxyanilino)nicotinic acid 
• 90-04-0 2-methoxy-phenylamine 
• 2942-59-8 2-chloronicotinic acid 
• 115892-33-6 cyanomethyl 2-(o-methoxyanilino)nicotinate 

Downstream Products

• 115892-02-9 4-Hydroxy-1-(2-methoxy-phenyl)-1H-[1,8]naphthyridin-2-one 
• 115892-08-5 4-Allyloxy-1-(2-methoxy-phenyl)-1H-[1,8]naphthyridin-2-one 
• 115891-47-9 2-[Acetyl-(2-methoxy-phenyl)-amino]-nicotinic acid methyl ester 

Relevant academic research and scientific papers

Antiallergy Agents. 1. Substituted 1,8-Naphthyridin-2(1H)-ones as Inhibitors of SRS-A Release

A novel class of antiallergy agents, the substituted 1,8-naphthyridin-2(1H)-ones, is described.The present compounds are orally active, potent inhibitors of allergic and nonallergic bronchospasm in animal models.Structure-activity studies of the lead compound in this sereis, 1-phenyl-3-n-butyl-4-hydroxynaphthyridin-2(1H)-one (11), identified three compounds of interest, 1-phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (12), 1-(3'-chlorophenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (87), and 1-(3'-methoxyphenyl)-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one (89).The mechanism of antiallergy activity may involve inhibition of the release of the sulfidopeptide leukotrienes. 1-Phenyl-3-(2-propenyl)-4-acetoxy-1,8-naphthyridin-2(1H)-one, Sch 33303 (12), was selected for preclinical development as an antiallergy agent.