114515-48-9

Upstream product

• 927-77-5 n-propylmagnesium bromide 
• 121-33-5 vanillin 
• 881-68-5 vanillin acetate 
• 10557-57-0 propylmagnesium iodide 

Downstream Products

• 59832-96-1 4-butylguaiacol 
• 64142-23-0 4-butyryl-1-hydroxy-2-methoxybenzene 

Relevant academic research and scientific papers

Tobacco smoke chemistry. 2. Alkyl and alkenyl substituted guaiacols found in cigarette smoke condensate.

A series of alkyl and alkenyl substituted guaiacols, which comprise a group of biologically and organoleptically active compounds, have been synthesized. Mass spectra and GC retention times for these have been recorded and compared with those obtained for constituents of a weakly acidic fraction of smoke condensate derived from American blend type cigarettes. On the basis of these results, 25 guaiacols have been identified, 18 of which have not been detected in tobacco smoke condensate previously.

Synthesis of Apocynin, a Choleretic Constituent of Picrorhiza kurroa and Its Homologues

Apocynin (4-hydroxy-3-methoxyacetophenone) and a few of its side chain homologues have been synthesized by a simple two-step procedure.The key step in the synthesis involves Grignard reaction between vanillin acetate and different haloalkanes.The carbinols thus generated have been dehydrogenated to the desired compounds by stirring with DDQ in benzene.The synthesised compounds show consistent choleretic activity in experimental animals.