114529-38-3Relevant academic research and scientific papers
Bi-aryl rotation in phenyl-dihydroimidazoquinoline catalysts for kinetic resolution of arylalkyl carbinols
Wang, Zheng,Ye, Jinjin,Wu, Rui,Liu, Yang-Zi,Fossey, John S.,Cheng, Jiagao,Deng, Wei-Ping
, p. 1909 - 1913 (2014/06/24)
Chiral nucleophilic catalysts, 6-aryl-phenyl-dihydroimidazoquinolines (PIQs), were designed, synthesised and applied to the kinetic resolution of arylalkyl carbinols with very high selectivity (S) factors (up to 530). Density functional theory calculations indicate that multiple noncovalent interactions play a key role in chiral recognition between 6-aryl-PIQ catalysts and chiral secondary alcohol substrates. The Royal Society of Chemistry 2014.
Optically pure bulky (hetero)arylalkyl carbinols via kinetic resolution
Hu, Bin,Meng, Meng,Fossey, John S.,Mo, Weimin,Hu, Xinquan,Deng, Wei-Ping
supporting information; experimental part, p. 10632 - 10634 (2011/10/30)
Planar chiral nucleophilic catalyst Fc-PIP was employed in the kinetic resolution of bulky (hetero)arylalkyl carbinols delivering unreacted alcohols with extremely high enantiomeric excess (>99.0% ees) in ideal conversions ranging from 50.4-56.7%.
