114530-61-9

Upstream product

• 64244-45-7 methyl (Z)-7-hydroxy-5-heptenoate 
• 76871-77-7 cis-7-hydroxy-5-heptenoic acid,methyl ester 
• 110452-43-2 2-(6-hydroxy-4-hexynyl)-1,3-dioxolane 
• 99249-48-6 (E)-7-hydroxyhept-5-enal 
• 81677-42-1 (E)-7-hydroxyhept-5-enoic acid 
• 110452-45-4 1,1-ethylenedioxy-5E-hepten-7-ol 
• 55797-81-4 C₂₆H₂₂O₈ 
• 66688-21-9 (E)-methyl 7-oxo-hept-5-enoate 
• 50781-91-4 methyl 7-hydroxy-5-heptynoate 
• 63753-78-6 C₃₀H₂₈O₉ 
• 73957-96-7 C₂₅H₂₆O₈ 
• 73957-95-6 C₃₂H₃₀O₁₀ 
• 73957-97-8 C₂₂H₂₄O₇ 
• 73957-98-9 C₂₉H₃₀O₉S 

Downstream Products

• 73958-00-6 methyl 10-formyl-5,6E-epoxy-7E,9E-decadienoate 
• 73958-10-8 (7E,9E,11Z,14Z)-(5S,6R)-6-[2-(4-Amino-4-carboxy-butyrylamino)-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid methyl ester 
• 73958-00-6 4-[(2S,3S)-3-((1Z,3E)-5-Oxo-penta-1,3-dienyl)-oxiranyl]-butyric acid methyl ester 
• 91944-21-7 (7E,9E,11Z,14Z)-6-[2-Amino-2-(carboxymethyl-carbamoyl)-ethylsulfanyl]-5-hydroxy-icosa-7,9,11,14-tetraenoic acid methyl ester 
• 89461-64-3 (7E,9E,11Z,14Z)-6-(2-Amino-2-carboxy-ethylsulfanyl)-5-hydroxy-icosa-7,9,11,14-tetraenoic acid methyl ester 
• 72025-60-6 leukotriene C1 
• 72297-14-4 methyl trans 5(S),6(S)-oxido-7-trans-9,11,14-cis-eicosatetraenoate 

Relevant academic research and scientific papers

Synthesis of epoxyisoprostanes: Effects in reducing secretion of pro-inflammatory cytokines IL-6 and IL-12

Anti-inflammatory: The efficient and general synthetic route to the elusive epoxyisoprostanoid phospholipids PECPC and PEIPC, along with the isoprostanoids EC and EI, relies on a number of stereo- and chemoselective steps, including a C-H insertion for the rapid construction of the cyclopentanone ring. The synthesized compounds display unprecedented biological activity in reducing the secretion of pro-inflammatory cytokines. Copyright

SYNTHESES OF PROSTAGLANDIN AND LEUKOTRIENE C7 SYNTHONS THROUGH COMMON INTERMEDIATE COMPOUNDS

A method is proposed for the production of the C7-synthons used in the synthesis of eicosanoids (the methyl esters of 7-hydroxy-5Z-heptenoic and 6-formyl-5,6-trans-epoxyhexanoic acids) by a common scheme from readily obtainable tetrahydrofuran and propargyl alcohol.

PROSTANOIDS. X. SYNTHESIS OF THE METHYL ESTER OF (+/-)-11,12,14,15-BISDEHYDROLEUCOTRIENE A4 AND ITS ANALOGS

The synthesis of the methyl ester of (+/-)-11,12,14,15-bisdehydroleucotriene A4 and its analogs was realized by means of the "C13 + C7" and "C13 + C8" schemes. (+/-)-6,7-Epoxy-1E,8E,10E-heneicosatriene-12,15-diyne, methyl (+/-)-4,5-cis-epoxy-8E,10E-heneicosadiene-12,15-diynoate, and the carbon analogs ethyl 5R,6S-dimethylmethano-7E,9E-eicosadiene-11,14-diynoate and 4R,5S-dimethylmethano-7E,9E-eicosadiene-11,14-diyn-2-one were synthesized.