114551-06-3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 81246-79-9 5'-dimethoxytrityluridine 
• 58-96-8 uridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 114551-07-4 2’,3’-anhydro-5’-O-(4,4’-dimethoxytrityl)-1-β-D-lyxofuranosyl-uracil 
• 114551-14-3 5'-O-(4,4'-dimethoxytrityl)-1-(3-deoxy-β-D-arabinofuranosyl)uracil 
• 110524-36-2 1-(3-deoxy-3-C-methyl-β-D-arabinofuranosyl)uracil 
• 114563-61-0 1-(2,3-anhydro-β-D-lyxofuranosyl)-4-(methylamino)-2(1H)-pyrimidinone 
• 114551-17-6 1-{(2R,3S,4S,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-hydroxy-4-methyl-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione 
• 114551-11-0 5'-O-(4,4'-dimethoxytrityl)-1-(2,3-anhydro-β-D-lyxofuranosyl)cytosine 
• 114551-10-9 1-{(1S,2R,4R,5S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,6-dioxa-bicyclo[3.1.0]hex-2-yl}-4-[1,2,4]triazol-1-yl-1H-pyrimidin-2-one 
• 114551-12-1 3’-azido-3’-deoxy-5’-O-(4,4’-dimethoxytrityl)-1-β-D-arabinofuranosyl-uracil 
• 6206-17-3 1-(3'-Azido-3'-desoxy-β-D-arabinofuranosyl)-uracil 
• 60786-48-3 4-amino-1-(3-azido-β-D-3-deoxy-arabinofuranosyl)-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Azido Functionalized Nucleosides Linked to Controlled Pore Glass as Suitable Starting Materials for Oligonucleotide Synthesis by the Phosphoramidite Approach

It has long been debated whether easily reducible azide groups can withstand the conditions of oligonucleotide synthesis by phosphoramidite chemistry. We have synthesized various 2′- and 3′-azido modified nucleosides and immobilized them on controlled pore glass (CPG) to be used as starting material for the synthesis of oligonucleotides (ONs) with 3′-terminal azide (attached to C2′ or C3′). In a model study, immobilized 3′-azidoadenosine was used as a starting block for the synthesis of a series of oligodeoxynucleotides (ODNs) of increasing length. Upon synthesis, the ODNs were enzymatically digested into monomers and analyzed by RP-HPLC. A peak corresponding to 3′-azidoadenosine was clearly identified in all samples. Quantitative analysis showed that 3′-azidoadenosine was present in nearly the expected ratio to deoxycytidine, which was used as an internal standard. Most importantly, the ratio remained the same for all three ODNs regardless of their length, demonstrating that a higher number of coupling cycles does not lead to higher degradation of the azide. Thus, 2′- or 3′-azido nucleosides attached to a solid support are excellent starting materials for the synthesis of oligonucleotides with 3′-terminal azide.

1-(2,3-anhydro-β-D-lyxofuranosyl)cytosine derivatives as potential inhibitors of the human immunodeficiency virus

We report here that 1-(2,3-anhydro-β-D-lyxofuranosyl)cytosine has activity against the human immunodeficiency virus in vitro. A number of 2',3'-anhydro-β-D-lyxofuranosyl nucleoside derivatives were prepared, but none had the activity of the title compound. New efficient procedures were developed for the synthesis of 3'-deoxy-3'-alkyl- and 3'-deoxy-β-D-arabinosylpyrimidine derivatives.