114554-23-3

Basic information

• Product Name: 2-(5-Methyl-1H-pyrazol-3-yl)-phenylaMine
• Synonyms: 2-(5-Methyl-1H-pyrazol-3-yl)-phenylaMine;[2-(3-methyl-1H-pyrazol-5-yl)phenyl]amine;2-(3-methyl-1H-pyrazol-5-yl)phenylamine;2-(5-methyl-1H-pyrazol-3-yl)aniline;MFCD03768458;Phenylamine, 2-(5-methyl-2H-pyrazol-3-yl)-;2-(5-Methyl-2H-pyrazol-3-yl)-phenylamine
• CAS NO: 114554-23-3
• Molecular Formula: C₁₀H₁₁N₃
• Molecular Weight: 173.21444
• Mol File: 114554-23-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 122 °C
• Boiling Point: 383.8±27.0 °C(Predicted)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• PKA: 13.65±0.10(Predicted)
• CAS DataBase Reference: 2-(5-Methyl-1H-pyrazol-3-yl)-phenylaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-Methyl-1H-pyrazol-3-yl)-phenylaMine(114554-23-3)
• EPA Substance Registry System: 2-(5-Methyl-1H-pyrazol-3-yl)-phenylaMine(114554-23-3)

Safety Data

• Hazardous Substances Data: 114554-23-3(Hazardous Substances Data)

Usage

General Description

2-(5-Methyl-1H-pyrazol-3-yl)-phenylamine is a chemical compound with the molecular formula C11H12N3. It is a derivative of phenylamine, with a pyrazole ring attached to the phenyl group at the 2 position. 2-(5-Methyl-1H-pyrazol-3-yl)-phenylaMine is commonly used as a building block in organic synthesis and pharmaceutical research. It exhibits potential biological activity and has been studied for its potential applications in drug development. Its structure and properties make it a valuable tool for the synthesis of various organic molecules and it is a popular starting material for the preparation of diverse organic compounds.

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Relevant articles and documents

Synthesis and evaluation of imidazole-4,5-and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus

The results of a high-throughput screening assay using the dengue virus-2 replicon showed that the imidazole 4,5-dicarboxamide (I45DC) derivative (15a) has a high dengue virus inhibitory activity. Based on 15a as a lead compound, a novel class of both disubstituted I45DCs and the resembling pyrazine 2,3-dicarboxamides (P23DCs) were synthesized. Here, we report on their in vitro inhibitory activity against dengue virus (DENV) and yellow fever virus (YFV). Some of these first generation compounds have shown activity against both viruses in the micromolar range. Within this series, compound 15b was observed to display the highest antiviral potency against YFV with an EC50 Combining double low line 1.85 μM. In addition, compounds 20a and 20b both potently inhibited replication of DENV (EC50 Combining double low line 0.93 μM) in Vero cells.

Synthesis and SAR study of new phenylimidazole-pyrazolo[1,5-c]quinazolines as potent phosphodiesterase 10A inhibitors

A series of phenylimidazole-pyrazolo[1,5-c]quinazolines 1a-q was designed, synthesized and characterised as a novel class of potent phophodiesterase 10A (PDE10A) inhibitors. In this series, 2,9-dimethyl-5-(2-(1-methyl-4-phenyl-1H- imidazol-2-yl)ethyl)pyrazolo[1,5-c]quinazoline (1q) showed the highest affinity for PDE10A enzyme (IC50 = 16 nM).