49612-00-2

Usage

Uses

Used in Pharmaceutical Research:
1-(2-METHYL-4-QUINOLYL)HYDRAZINE is used as a research compound for investigating the biological activities and potential therapeutic applications of hydrazine derivatives. Its unique structure, which includes a quinoline ring and a methyl substituent, makes it a valuable tool in the discovery and development of new pharmaceutical agents.
Used in Drug Development:
In the pharmaceutical industry, 1-(2-METHYL-4-QUINOLYL)HYDRAZINE is used as a starting material or intermediate in the synthesis of various drug candidates. Its specific properties and reactivity can be leveraged to create novel compounds with potential therapeutic benefits.
Used in Chemical Synthesis:
1-(2-METHYL-4-QUINOLYL)HYDRAZINE is utilized as a building block in the synthesis of complex organic molecules and other chemical compounds. Its versatility and reactivity make it a valuable component in the creation of new materials and products across various industries.

Upstream product

• 4295-06-1 4-chloro-2-methylquinoline 
• 6287-35-0 ethyl 3-anilinocrotonate 
• 62-53-3 aniline 

Downstream Products

• 1392812-53-1 2-(4-cyanobenzylidene)-1-(2-methylquinolin-4-yl)hydrazine 
• 1038623-44-7 N-{4-[bis(2-chloroethyl)amino]phenyl}-2-(2-methyl-4-quinolinyl)hydrazinecarboxamide 
• 114554-23-3 2-(3-methyl-1H-pyrazol-5-yl)aniline 
• 32113-04-5 4-azido-2-methylquinoline 
• 6628-04-2 4-amino-2-methylquinoline 

Relevant academic research and scientific papers

Solid-supported hydrazone of 4-(4′-Formyl-3′-methoxyphenoxy)butyric acid as a new traceless linker for solid-phase synthesis

The use of a hydrazine derived from a backbone amide linker as a new hydrazone-based traceless linker for solid-phase organic synthesis is described. The stability of the linker was tested under various conditions, including treatment with acids, bases, and borohydrides. Final compounds can be released by selective cleavage using trimethylsilanolate. To demonstrate the versatility of the linker, the synthesis of a model compound under various reaction conditions was performed with good results.

N1-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethylene-N 2-(2-methylquinoline-4-yl)hydrazine derivatives as antiplasmodial falcipain-2 inhibitors

A series of N1-{4-[(10S)-dihydroartemisinin- 10-oxyl]}phenylmethylene-N2-(2-methylquinoline-4-yl) hydrazine derivatives 9a-9n possessing 4-quinolylhydrazone and artemisinin cores were herein synthesized and evaluated for their activities against cysteine protease falcipain- 2 of Plasmodium falciparum. The structures were clearly confirmed by elemental analysis, 1H NMR, and mass spectra. The pharmacological results indicated that all compounds showed excellent activity against recombinant falcipain-2 (IC50 = 0.15-2.28 μM). The best one of this series was compound 9d (IC50 = 0.15 μM). The molecular docking results showed that the compound 9d made close contact with the key active site of cysteine protease falcipain-2.

Synthesis and some transformations of 6(8)-substituted 4-hydrazino-2- methylquinolines

6(8)-Substituted 4-hydrazino-2-methylquinolines were synthesized by reaction of the corresponding 4-chloro-2-methylquinolines with hydrazine hydrate. Reactions of the title compounds with ethyl acetoacetate and acetone gave 2,4-dimethyl-1H-pyrrolo[3,2-c]q

ANILINE OR PHENOL MUSTARDS LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE AROMATIC RINGS AND THEIR USE AS CANCER THERAPEUTIC AGENTS

New aniline or phenol N-mustards linked to DNA-affinity carriers (such as 9-anilinoacridines, acridines andquinolines), aminobenzamides or aminophenol ethers by a urea, carbamic acid, carbanic acid ester, hydxazine urea, hydrazine carbamic acid ester, phenoxyurea, phenoxycarbamic acid ester linkage with improved chemical stability and anti-tumor therapeutic efficacy are provided.