114564-83-9

Upstream product

• 495-69-2 Hippuric Acid 
• 98-88-4 benzoyl chloride 
• 1119-33-1 (S)-2-Amino-pentanedioic acid 5-ethyl ester 
• 124126-79-0 N-benzoyl-L-glutamic acid γ-ethyl ester 
• 1199-01-5 2-phenylazlactone 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 91387-29-0 ethyl 3-prop-1-yne-1-carboxylate 
• 83544-54-1 Ethyl 4-(benzoylamino)-3-oxobutanoate 

Downstream Products

• 1227164-57-9 (2-phenyloxazol-5-yl)methyl acetate 

Relevant academic research and scientific papers

One-pot conversion of amino acids into 2,5-disubstituted oxazoles: No metals needed

2,5-Disubstituted oxazoles with a variety of alkyl and aryl groups are efficiently formed from N-acylamino acids, by a one-pot radical decarboxylation- oxidation-enolization and iodine-promoted cyclization process. Remarkably, the reaction takes place under mild conditions, and no metal catalysis is needed. The process can be useful for the direct modification of small peptides.

One-pot synthesis of 2,4,5-trisubstituted oxazoles from N-acyl amino acids by a combination of cyclodehydration with N,N′-diisopropylcarbodiimide and Wittig olefination

By a combination of cyclodehydration of N-acyl amino acids with N,N′-diisopropylcarbodiimide (DIC) and non-classical Wittig olefination of the resultant 5(4H)-oxazolones with Ph3PCHCN and Ph 3PCHCOOEt, 5-oxazoleacetonitriles and 5-oxazoleacetates were synthesized in one-pot in 41-85% and 57-70% yields, respectively.

Compounds Which Selectively Modulate The CB2 Receptor

Compounds of formula (I) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

Studies on phosphonium ylides XXV: The behavior of active phosphacumulene and stabilized alkylidenephosphoranes towards 5-(4H)-oxazolones

The reaction of 2-phenyl-5-(4H)-oxazolone 1 and its 4-benzylidene derivative 2 with oxovinylidenetriphenylphosphorane 3 afforded 2-phenylfuro [3,2-d] [1,3]oxazol-5-(6H)-one 6 and 2,7-diphenyl-5H-pyrano[3,2-d][1,3]oxazol-5- one 7 along with triphenylphosph

A practical method for oxazole synthesis by cycloisomerization of propargyl amides

(Chemical Equation Presented) 2,5-Disubstituted and 2,4,5-trisubstituted oxazol-5-yl carbonyl compounds were prepared in good yields by a mild SiO 2-mediated cycloisomerization of propargyl amides.