1145669-50-6

Basic information

• Product Name: 5-O-hexanoyl-7-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl) apigenin
• Synonyms: 5-O-hexanoyl-7-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl) apigenin
• CAS NO: 1145669-50-6
• Molecular Weight: 1405.43
• Mol File: 1145669-50-6.mol

Chemical Properties

• CAS DataBase Reference: 5-O-hexanoyl-7-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl) apigenin(CAS DataBase Reference)
• NIST Chemistry Reference: 5-O-hexanoyl-7-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl) apigenin(1145669-50-6)
• EPA Substance Registry System: 5-O-hexanoyl-7-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl) apigenin(1145669-50-6)

Safety Data

• Hazardous Substances Data: 1145669-50-6(Hazardous Substances Data)

Upstream product

• 1145669-49-3 5-O-hexanoyl-apigenin-7-yl-2,3,4,6-tetra-O-benzoyl-β-D-glucopyranoside 
• 14218-11-2 2,3,4,6-tetra-O-benzoylglucosyl bromide 
• 1145669-54-0 5-O-hexanoylapigenin-4'-yl-2,3,4-tri-O-benzoyl-α-L-rhamnopyranoside 

Downstream Products

• 1145669-55-1 7-O-β-D-glucopyranosyl-4'-O-α-L-rhamnopyranosyl-apigenin 

Relevant articles and documents

The first total synthesis of 7-O-β-d-glucopyranosyl-4′-O-α-l-rhamnopyranosyl apigenin via a hexanoyl ester-based protection strategy

The first total synthesis of 7-O-β-d-glucopyranosyl-4′-O-α-l-rhamnopyranosyl apigenin 1, which exhibits good anti-hepatitis B virus and anti-stroke activities, was accomplished in six steps and 20% overall yield from apigenin. Another synthetic route, in which the target was obtained in seven steps, was also developed to prove the utility of a hexanoyl ester-based orthogonal protection strategy. The hexanoyl protection strategy provided all the flavonoid intermediates with good solubility and reactivity, enabled efficient selective protection and glycosylation, and provided a practical and effective synthetic strategy for flavonoids, starting from commercially available flavone.