114574-46-8Relevant academic research and scientific papers
A simple method for the synthesis of 4-aryl-9-oxynaphthofuranone lignans
Kobayashi, Kazuhiro,Maeda, Kouji,Uneda, Tomokazu,Morikawa, Osamu,Konishi, Hisatoshi
, p. 443 - 446 (1997)
The 9-aryl-4-oxynaphthofuran-1(3H)-one system is generally synthesized in two steps from α-aryl-o-toluic acid derivatives. The method involves a tandem conjugate addition-Dieckmann type condensation between α-lithiated α-aryl-o-toluic acid derivatives and
Arylnaphthalene lignans as novel series of hypolipidemic agents raising high-density lipoprotein level
Iwasaki,Kondo,Nishitani,Kuroda,Hirakoso,Ohtani,Takashima
, p. 1701 - 1705 (2007/10/03)
A series of arylnaphthalene lignans were synthesized and tested for hypolipidemic activity. The most potent compound (4b) (TA-7552) not only reduced serum cholesterol, but also increased high-density lipoproteins cholesterol in rats. The effective dose of
