114579-92-9Relevant academic research and scientific papers
Diastereoselective and Enantiospecific Synthesis of 1,3-Diamines via 2-Azaallyl Anion Benzylic Ring-Opening of Aziridines
Li, Kangnan,Weber, Alexandria E.,Tseng, Luke,Malcolmson, Steven J.
supporting information, p. 4239 - 4242 (2017/08/23)
The 1,3-diamine motif appears in numerous complex molecules, yet there are few methods for the stereoselective construction of this moiety. Herein, we demonstrate a stereocontrolled synthesis of 1,3-diamines, which bear up to three contiguous stereogenic centers, through benzylic ring-opening of aziridines with 2-azaallyl anion nucleophiles. Reactions proceed efficiently (yield up to 95%), diastereoselectively (dr up to >20:1), site selectively, and enantiospecifically to deliver products with differentiated amino groups.
ARENE-CHROMIUM-TRICARBONYL COMPLEXES: STEREOSELECTIVE REACTIONS WITH ISOCYANIDE
Solladie-Cavallo, A.,Quazzotti, S.,Colonna, S.,Manfredi, A.
, p. 2933 - 2936 (2007/10/02)
More than 98 percent of A.I. is obtained during addition of TosMic with chiral complexes 2 and 3.The diastereoselectivity of the formation of the oxazolines is studied and the diastereomers clearly assigned.Orbital-interactions and electronic repulsions s
Highly Diastereoselective Synthesis of Aminoalcohols of Ephedrine Type
Solladie-Cavallo, Arlette,Dreyfus, Anne-Claire,Sanch, Francois,Klein, Arlette
, p. 1583 - 1586 (2007/10/02)
Analogs of ephedrine are obtained in 80percent yield in 3 steps from chiral arenechromium tricarbonyl complexes.Hence optically pure complexes afford optically pure analogs of ephedrine.
