1145869-48-2Relevant academic research and scientific papers
Azido nucleosides and nucleotide analogs
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, (2016/06/13)
Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4′-azidocytidine against hepatitis C virus replication: The discovery of 4′-azido-2′-deoxy-2′-fluorocytidine and 4′-azido-2′-dideoxy-2′,2′-difluorocytidine
Smith, David B.,Kalayanov, Genadiy,Sund, Christian,Winqvist, Anna,Maltseva, Tatiana,Leveque, Vincent J.-P.,Rajyaguru, Sonal,Le Pogam, Sophie,Najera, Isabel,Benkestock, Kurt,Zhou, Xiao-Xiong,Kaiser, Ann C.,Maag, Hans,Cammack, Nick,Martin, Joseph A.,Swallow, Steven,Johansson, Nils Gunnar,Klumpp, Klaus,Smith, Mark
experimental part, p. 2971 - 2978 (2010/02/28)
The discovery of 4′-azidocytidine (3) (R1479) (J. Biol. Chem. 2006, 281, 3793; Bioorg. Med. Chem. Lett. 2007, 17, 2570) as a potent inhibitor of RNA synthesis by NS5B (EC50 = 1.28 μM), the RNA polymerase encoded by hepatitis C virus (HCV), has led to the
