1145878-98-3 Usage
Uses
Used in Pharmaceutical Applications:
Gal-PUGNAc is used as an inhibitor for [β-hexosaminidases HEXA and HEXB] for [modulating their activity in tissue culture and increasing ganglioside GM2 levels in neuroblastoma cells]. This application is particularly relevant in the context of neurodegenerative diseases and cancer research, where understanding and manipulating the activity of these enzymes can lead to potential therapeutic strategies.
Used in Research and Development:
In the field of research and development, Gal-PUGNAc is used as a tool to study the function and regulation of β-hexosaminidases HEXA and HEXB. By inhibiting these enzymes, researchers can gain insights into their roles in various biological processes and potentially identify new targets for therapeutic intervention.
Used in Neurodegenerative Disease Research:
Gal-PUGNAc is used as a research compound for [investigating the role of HEXA and HEXB in neurodegenerative diseases]. The modulation of these enzymes' activity and the subsequent increase in ganglioside GM2 levels can provide valuable information on the underlying mechanisms of these diseases and help in the development of novel treatment strategies.
Used in Cancer Research:
In cancer research, Gal-PUGNAc is used as a compound to study its effects on neuroblastoma cells, particularly in relation to the increase in ganglioside GM2 levels. This information can be crucial for understanding the role of these enzymes in cancer cell biology and may contribute to the development of targeted therapies for specific types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1145878-98-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,5,8,7 and 8 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1145878-98:
(9*1)+(8*1)+(7*4)+(6*5)+(5*8)+(4*7)+(3*8)+(2*9)+(1*8)=193
193 % 10 = 3
So 1145878-98-3 is a valid CAS Registry Number.
1145878-98-3Relevant academic research and scientific papers
A selective inhibitor Gal-PUGNAc of human lysosomal β-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells
Stubbs, Keith A.,Macauley, Matthew S.,Vocadlo, David J.
supporting information; experimental part, p. 1300 - 1303 (2009/06/30)
β-hexosaminidases HEXA and HEXB is cell-permeable and modulates the acitivity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels. Gal-PUGNAc should allow the role of these enzymes to be studied at the cellular level without generating a
