1145906-07-5Relevant academic research and scientific papers
Synthesis and QSAR studies of 4-oxo-thiazolidines and 2-oxo-azetidines as potential antibacterial agents
Desai,Shah,Bhavsar,Saxena
, p. 1135 - 1144 (2008/12/23)
Several 2-(4-chlorophenyl)-N-(4-oxo-2-aryl(1,3,thiazolidin-3-yl))acetamides 2, N-[3-chloro-4-(2-aryl)-2-oxo-azetidinyl]-2-(4-chlorophenyl)acetamides 3, N-(4-oxo-2-aryl(1,3,-thiadiazolidin-3-yl){4-[5-oxo-2-phenyl-4-(phenylmethylene) (2-imidazolinyl)phenyl}carboxamides 7 and N-(3-chloro-2-oxo-4-arylazetidinyl){4- [5-oxo-2-phenyl-4-(phenylmethylene)(2imidazolinyl)] phenyl}carboxamides 8 have been synthesized and evaluated for their antibacterial activity against gram +ve and gram -ve bacteria i.e. S. aureus and E. coli. Most of the compounds are showed moderate to good activity against gram +ve and gram -ve bacteria. The QSAR studies of these compounds have been carried out in terms of structural and physicochemical parameters where positive contribution of substituents present at position-3 of N-[3-chloro-4-(2-aryl)-2-oxo-azetidinyl]-2-(4-chlorophenyl) acetamides with bulkier group indicating increase in hydrophobicity or steric bulk character.
