114597-35-2

Upstream product

• 114597-34-1 (2S,3R)-3-benzyloxymethoxy-2-[(4S,5R,6R)-6-[(1R)-2-tert-butyldiphenylsilyloxy-1-methylethyl]-2,2,5-trimethyl[1,3]dioxan-4-yl]-5-[1,3]dioxolanepentane 
• 106734-78-5 <2R<2α,3α,4β,5α,6β(1S*,2R*)>>-2-<(3,4-dimethoxyphenyl)methoxy>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>tetrahydro-3,5-dimethyl-2H-pyran-4-ol 
• 114597-33-0 (2R,3R,4R,5R,6R,7R)-7-Benzyloxymethoxy-1-(tert-butyl-diphenyl-silanyloxy)-9-[1,3]dioxolan-2-yl-2,4,6-trimethyl-nonane-3,5-diol 
• 106761-50-6 <2R<2α,3α,5α,6β,(1S*,2R*)>>-2-<(3,4-dimethoxyphenyl)methoxy>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>tetrahydro-3,5-dimethyl-4H-pyran-4-one 
• 106734-77-4 <2R<2α(1S*,2R*),3β,6β>>-6-<(3,4-dimethoxyphenyl)methoxy>-2-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-3,6-dihydro-3,5-dimethyl-2H-pyran 
• 106734-75-2 <2S<2α(1R*,2S*),3β>>-2-<4-(1,3-dioxolan-2yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-2,3-dihydro-3,5-dimethyl-4H-pyran-4-one 
• 114597-32-9 (2R,3R,4R,5R,6R,7R)-7-Benzyloxymethoxy-9-[1,3]dioxolan-2-yl-2,4,6-trimethyl-nonane-1,3,5-triol 
• 106734-76-3 (2R,3R,4R)-2-((1S,2R)-2-Benzyloxymethoxy-4-[1,3]dioxolan-2-yl-1-methyl-butyl)-3,5-dimethyl-3,4-dihydro-2H-pyran-4-ol 
• 106734-74-1 -α-methyl-β-<(phenylmethoxy)methoxy>-1,3-dioxolane-2-pentanal 
• 106734-73-0 (3R,4R)-2-<4-methyl-3-<(phenylmethoxy)methoxy>-5-hexenyl>-1,3-dioxolane 
• 106734-71-8 (3R,4S)-(1,3.dioxolan-2-yl)-4-methyl-5-(trimethylsilyl)-5-hexen-3-ol 
• 106734-72-9 (3R,4R)-(1,3-dioxolan-2-yl)-4-methyl-5-hexen-3-ol 
• 37610-80-3 1,3-dioxolan-2-ylethylmagnesium bromide 
• 3587-60-8 Benzyloxymethyl chloride 

Downstream Products

• 106734-84-3 <4R<4α,5β,6α(1S*,2R*)>>-2-<1-<6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-2,2,5-trimethyl-1,3-dioxan-4-yl>ethyl>-2,3-dihydro-3-methyl-4H-pyran-4-one 
• 114673-25-5 threo aldol 
• 106734-82-1 <4S<4α(R*),5β,6α(1R*,2S*)>>-6-<4-(1,3-dioxolan-2-yl)-1-methyl-2-<(phenylmethoxy)methoxy>butyl>-α,2,2,5-tetramethyl-1,3-dioxane-4-acetaldehyde 

Relevant academic research and scientific papers

Total synthesis of zincophorin

The total synthesis of the title compound, which is a zinc-binding antibiotic, is described. The synthesis starts with aldehyde 4 and Grignard reagent 6. The key steps are (i) the cyclocondensation of aldehyde 10 with diene 11 under the influence of magnesium bromide, (ii) the cyclocondensation of aldehyde 24 with diene 33 under the influence of BF3·OEt2, (iii) the carbon Ferrier reaction of glycal acetate 37 with (E)-crotyltrimethylsilane, and (iv) the reductive merger of aldehyde 2a with sulfone 3.