37610-80-3Relevant articles and documents
Enantioselective Synthesis of Cyclic Nitrones by Chemoselective Intramolecular Allylic Alkylation of Oximes
Sandmeier, Tobias,Carreira, Erick M.
supporting information, p. 9913 - 9918 (2021/03/29)
The enantio- and chemoselective iridium-catalyzed N-allylation of oximes is described for the first time. Intramolecular kinetic resolution provides access to cyclic nitrones and enantioenriched aliphatic allylic alcohols. Salient features of this transformation are its ability to employ E/Z-isomeric mixtures of oxime starting materials convergently and high functional group tolerance. The implementation of N-allylation/1,3-dipolar cycloaddition reaction sequences furnishes tricyclic isoxazolidines in highly enantio- and diastereoselective fashion. The synthetic utility of the approach is demonstrated by the efficient, formal synthesis of the marine natural product (+)-halichlorine.
DIAZASPIRODECANE OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 27-28, (2008/06/13)
The present invention is directed to diazaspirodecane compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
An efficient synthesis of cholanic acids from 20-ketopregnanes
Fukumoto,Suzuki,Nemoto,et al.
, p. 3701 - 3704 (2007/10/02)
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