1146066-33-2Relevant academic research and scientific papers
Computational evaluation and experimental verification of antibacterial and antioxidant activity of 7-hydroxy-3-pyrazolyl-4H-chromen-4-ones and their o-glucosides: Identification of pharmacophore sites
Sheikh, Javed,Hatzade, Kishor,Bader, Ammar,Shaheen, Usama,Sander, Thomas,Ben Hadda, Taibi
, p. 243 - 251 (2014/03/21)
This paper reports the computational evaluation and experimental verification of 7-hydroxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl)-4H-chromen-4-ones 3 and their o-β-d-glucopyranosides 5 for their antimicrobial and antioxidant activity. The prepared compounds
Synthesis, structural determination, and biological activity of new 7-hydroxy-3-pyrazolyl-4H-chromen- 4-ones and their o-β-D-glucosides
Hatzade, Kishor,Taile, Vijay,Gaidhane, Pravin,Ingle, Vishwas
experimental part, p. 241 - 254 (2010/11/05)
A convenient route to synthesize some new medicinally important 7-hydroxy-3-pyrazolyl chromones (3ai) is described. The interaction of 7-hydroxy-3-formyl chromone (1) with various substituted acetophenones and further cyclization with hydrazine hydrate in an aprotic solvent followed by condensation with 2, 3, 4, 6-tetra-o-acetyl-a-d-glucopyranosyl bromide afforded 2, 3, 4, 6-tetra-o-acetyl-β -d-glucopyranosyloxy- 3-(3-aryl-1H-pyrazol-5- yl)-4H-chromen-4-ones (4a-i). Later deacetylation with anhydrous zinc acetate in methanol gave 7-o-β -d-glucopyranosyloxy-3-(3-aryl-1H -pyrazol-5-yl)-4H- chromen-4-ones (5a-i). These compounds were evaluated for their in vitro antimicrobial and anti-oxidant activity. The structures of these newly synthesized o-glucosides were established by IR, NMR, mass spectra, elemental analysis, and chemical analysis. TUeBITAK.
Synthesis and biological activities of new 7-O-β-D-glueopyranosyloxy- 3-(3-oxo-3-arylprop-1-enyl)-chromones
Hatzade,Taile,Gaidhane,Umare,Haldar,Ingle
experimental part, p. 1548 - 1557 (2010/03/30)
A convenient route to synthesize some new medicinally important 7-hydroxy-3-(3-oxo-3-arylprop-l-enyl)-chromones 2 is described by the interaction of 7-hydroxy-3-formyl chromone 1 with various substituted acetophenones which on condensation with 2,3,4,6-te
Synthesis and biological activities of new hydroxy-3-pyrazolyl-4H-chromen- 4-ones and their O-glucosides
Hatzade,Taile,Gaidhane,Haldar,Ingle
experimental part, p. 1260 - 1270 (2009/04/11)
The synthesis of a number of 7-hydroxy-3-pyrazolyl-chromen-4H-ones and their o-glucosides has been described. 7-Hydoxy-3-formyl chromen-4H-one 1 on condensation with substituted acetophenones in the presence of piperidine in dry alcohol affords 7-hydroxy-3-(3-oxo-3-arylprop-1-enyl)-4H-chromen-4-ones 2 which on cyclization with phenyl hydrazine hydrochloride leads to the formation of 7-hydroxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl)-4H-chromen-4-ones 3. 7-o-β-D-Glucopyranosyloxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl) -4H-chromen-4-ones 5 have been synthesized by the reaction of 2, 3, 4, 6-tetra-o-acetyl-α-D-glucopyranosyl bromide with potassium salt of 3 followed by deacetylation with Zn(CH3COO)2 in absolute methanol. Some of the newly synthesized compounds have been screened for their antimicrobial and antioxidant activity.
