1146210-65-2

Basic information

• Product Name: Benzenecarbodithioic acid, 2,5-difluoro-, Methyl ester
• Synonyms: Benzenecarbodithioic acid, 2,5-difluoro-, Methyl ester;Methyl 2,5-difluorobenzodithioate
• CAS NO: 1146210-65-2
• Molecular Formula: C₈H₆F₂S₂
• Molecular Weight: 204.2600464
• Mol File: 1146210-65-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenecarbodithioic acid, 2,5-difluoro-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarbodithioic acid, 2,5-difluoro-, Methyl ester(1146210-65-2)
• EPA Substance Registry System: Benzenecarbodithioic acid, 2,5-difluoro-, Methyl ester(1146210-65-2)

Safety Data

• Hazardous Substances Data: 1146210-65-2(Hazardous Substances Data)

Upstream product

• 1146210-64-1 C₈H₆F₂OS 

Downstream Products

• 1018690-17-9 2,5-difluorothiobenzoyl hydrazide; hydrochloride 
• 1259928-69-2 C₁₄H₆F₄N₂S 

Relevant articles and documents

Synthesis, determination of absolute configuration, and biological evaluation of spiro-fused thiadiazoline inhibitors of kinesin spindle protein (KSP)

A facile and highly convergent synthesis of biologically active spiro-fused thiadiazoline KSP inhibitors is reported. The highlights of the synthesis include the Michael reaction and cyclization of thiosemicarbazone to 1,3,4-thiadiazoline. This chemistry lends itself to the preparation of (+)-2, a potent and orally bioavailable anti-cancer agent, and to the development of a structure-activity relationship program.

SPIRO-CONDENSED 1, 3, 4-THIADIAZOLE DERIVATIVES FOR INHIBITING KSP KINESIN ACTIVITY

The present invention relates to compounds of Formula (I), below, (wherein X, R1, R2, R3, p, E, ring A, and ring B are as defined herein). The present invention also relates to compositions (including pharmaceutically acceptable compositions) comprising t