1146290-36-9 Usage
Uses
Used in Chemical Research:
2-fluoro-4-nitrobenzene-1-sulfonyl chloride is used as a reagent in chemical research for its high reactivity and versatility. It is involved in various organic synthesis processes, making it a valuable component in the development of new compounds and materials.
Used in Organic Synthesis:
In the field of organic synthesis, 2-fluoro-4-nitrobenzene-1-sulfonyl chloride is used as a key intermediate for the preparation of a wide range of chemical products. Its reactivity allows for the formation of new bonds and the creation of complex molecular structures, which are essential in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Substitution Reactions:
2-fluoro-4-nitrobenzene-1-sulfonyl chloride is used as a reactant in substitution reactions, where an amino group replaces the sulfonyl chloride group. This reaction is crucial in the synthesis of various functionalized aromatic compounds, which have applications in different industries, such as the production of dyes, pigments, and pharmaceuticals.
Used in Drug Development:
In the pharmaceutical industry, 2-fluoro-4-nitrobenzene-1-sulfonyl chloride is used as a building block for the synthesis of drug candidates. Its reactivity and functional groups enable the creation of novel molecular structures with potential therapeutic properties, contributing to the development of new medications for the treatment of various diseases.
Used in Material Science:
2-fluoro-4-nitrobenzene-1-sulfonyl chloride is used as a precursor in the synthesis of advanced materials, such as polymers and composites, with unique properties. Its incorporation into these materials can lead to improved performance characteristics, such as enhanced stability, increased strength, or specific interactions with other molecules, making them suitable for various applications in industries like electronics, aerospace, and automotive.
Check Digit Verification of cas no
The CAS Registry Mumber 1146290-36-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,6,2,9 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1146290-36:
(9*1)+(8*1)+(7*4)+(6*6)+(5*2)+(4*9)+(3*0)+(2*3)+(1*6)=139
139 % 10 = 9
So 1146290-36-9 is a valid CAS Registry Number.
1146290-36-9Relevant academic research and scientific papers
3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF
-
, (2017/10/06)
The present invention provides compounds, compositions thereof, and methods of using the same.
[11C]GSK2126458 and [18F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers
Wang, Min,Gao, Mingzhang,Miller, Kathy D.,Sledge, George W.,Zheng, Qi-Huang
, p. 1569 - 1574 (2012/04/04)
GSK2126458 is a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with low picomolar to subnanomolar activity. [11C]GSK2126458 and [18F]GSK212 6458, new potential PET agents for imaging of PI3K and mTOR in cancer, were first designed and synthesized in 40-50% and 20-30% decay corrected radiochemical yield, and 370-740 and 37-222 GBq/lmol specific activity at end of bombardment (EOB), respectively.
Synthesis of isomeric fluoronitrobenzene-sulfonyl chlorides
Zhersh, Sergey,Lukin, Oleg,Matvienko, Vitaly,Tolmachev, Andrey
experimental part, p. 5982 - 5986 (2010/10/01)
The synthesis of five hitherto unknown isomeric fluoronitrobenzenesulfonyl chlorides is described. The compounds are prepared from difluoronitrobenzenes by a two-step procedure. In the first step the starting compounds undergo a regioselective reaction with phenylmethanethiol giving rise to the corresponding thioethers. The oxidative cleavage of the latter with chlorine results in the sulfonyl chlorides in good yields. One example of a threefold sequential functionalization of 2-fluoro-6-nitrobenzenesulfonyl chloride showing the synthetic utility of the title compounds is provided.
