1242618-52-5

Usage

Structure

Benzene derivative with a fluorine atom at the 2-position, a nitro group at the 4-position, and a benzylsulfanyl group attached to the 1-position.

Type of compound

Organic chemical compound

Applications

a. Organic synthesis
b. Pharmaceutical research
c. Potential use in the development of new drugs, agrochemicals, and materials

Hazards

a. May pose hazards to human health
b. May pose hazards to the environment
c. Importance of careful handling and safety precautions during use and storage.

Upstream product

• 369-34-6 3,4-difluoronitrobenzene 
• 100-53-8 phenylmethanethiol 
• 100-44-7 benzyl chloride 
• 350-31-2 1-chloro-2-fluoro-4-nitrobenzene 

Downstream Products

• 1146290-36-9 2-fluoro-4-nitrobenzene-1-sulfonyl chloride 
• 1360537-76-3 2-fluoro-4-[⁽¹⁸⁾F]fluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide 
• 1360537-72-9 2-fluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)-4-nitrobenzenesulfonamide 
• 1360537-70-7 N-(5-bromo-2-methoxypyridin-3-yl)-2-fluoro-4-nitrobenzenesulfonamide 

Relevant academic research and scientific papers

USP30 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

An odorless, one-pot synthesis of nitroaryl thioethers via SNAr reactions through the in situ generation of S-alkylisothiouronium salts

A newly developed C-S bond formation nucleophilic aromatic substitution (SNAr) reaction in aqueous Triton X-100 (TX100) micelles has been disclosed. This chemistry, in which odorless, cheap and stable thiourea in place of thiols is used as the sulfur reagent, provides an efficient approach for the generation of nitroaryl thioethers, which are useful structural units of many bioactive molecules, rendering this methodology attractive to both synthetic and medicinal chemistry.

[11C]GSK2126458 and [18F]GSK2126458, the first radiosynthesis of new potential PET agents for imaging of PI3K and mTOR in cancers

GSK2126458 is a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with low picomolar to subnanomolar activity. [11C]GSK2126458 and [18F]GSK212 6458, new potential PET agents for imaging of PI3K and mTOR in cancer, were first designed and synthesized in 40-50% and 20-30% decay corrected radiochemical yield, and 370-740 and 37-222 GBq/lmol specific activity at end of bombardment (EOB), respectively.

Synthesis of isomeric fluoronitrobenzene-sulfonyl chlorides

The synthesis of five hitherto unknown isomeric fluoronitrobenzenesulfonyl chlorides is described. The compounds are prepared from difluoronitrobenzenes by a two-step procedure. In the first step the starting compounds undergo a regioselective reaction with phenylmethanethiol giving rise to the corresponding thioethers. The oxidative cleavage of the latter with chlorine results in the sulfonyl chlorides in good yields. One example of a threefold sequential functionalization of 2-fluoro-6-nitrobenzenesulfonyl chloride showing the synthetic utility of the title compounds is provided.