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1146395-46-1

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  • Benzeneacetamide, 4-(3-methyl-2-pyrazinyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]-

    Cas No: 1146395-46-1

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1146395-46-1 Usage

General Description

Benzeneacetamide, 4-(3-methyl-2-pyrazinyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]- is a complex chemical compound with a long name. It contains benzeneacetamide, a molecular structure that includes a benzene ring and an amide functional group. Additionally, it consists of a 4-(3-methyl-2-pyrazinyl) group and an N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl] group. Benzeneacetamide, 4-(3-methyl-2-pyrazinyl)-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)-2-pyridinyl]ethyl]- likely has diverse chemical properties and potential applications, although further research and analysis would be needed to fully understand its characteristics.

Check Digit Verification of cas no

The CAS Registry Mumber 1146395-46-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,6,3,9 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1146395-46:
(9*1)+(8*1)+(7*4)+(6*6)+(5*3)+(4*9)+(3*5)+(2*4)+(1*6)=161
161 % 10 = 1
So 1146395-46-1 is a valid CAS Registry Number.

1146395-46-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[4-(3-Methyl-2-pyrazinyl)phenyl]-N-{(1R)-1-[5-(2,2,2-trifluoroe thoxy)-2-pyridinyl]ethyl}acetamide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1146395-46-1 SDS

1146395-46-1Downstream Products

1146395-46-1Relevant articles and documents

Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents

Yang, Zhi-Qiang,Schlegel, Kelly-Ann S.,Shu, Youheng,Reger, Thomas S.,Cube, Rowena,Mattern, Christa,Coleman, Paul J.,Small, Jim,Hartman, George D.,Ballard, Jeanine,Tang, Cuyue,Kuo, Yuhsin,Prueksaritanont, Thomayant,Nuss, Cindy E.,Doran, Scott,Fox, Steve V.,Garson, Susan L.,Li, Yuxing,Kraus, Richard L.,Uebele, Victor N.,Taylor, Adekemi B.,Zeng, Wei,Fang, Wei,Chavez-Eng, Cynthia,Troyer, Matthew D.,Luk, Julie Ann,Laethem, Tine,Cook, William O.,Renger, John J.,Barrow, James C.

scheme or table, p. 504 - 509 (2011/03/20)

A novel phenyl acetamide series of short-acting T-type calcium channel antagonists has been identified and evaluated using in vitro and in vivo assays. Heterocycle substitutions of the 4-position of the phenyl acetamides afforded potent and selective antagonists that exhibited desired short plasma half-lives across preclinical species. Lead compound TTA-A8 emerged as a compound with excellent in vivo efficacy as indicated by its significant modulation of rat sleep architecture in an EEG telemetry model, favorable pharmacokinetic properties, and excellent preclinical safety. TTA-A8 recently progressed into human clinical trials, and in line with our predictions, preliminary studies (n = 12) with a 20 mg oral dose afforded a high Cmax of 1.82 ± 0.274 μM with an apparent terminal half-life of 3.0 ± 1.1 h.

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