1146434-31-2Relevant academic research and scientific papers
Total synthesis of spiruchostatin A via chemoselective macrocyclization using an accessible enantiomerically pure latent thioester
Calandra, Nicole A.,Cheng, Yim Ling,Kocak, Kimberly A.,Miller, Justin S.
supporting information; experimental part, p. 1971 - 1974 (2009/09/08)
HDAC inhibitor Spiruchostatin A was synthesized via a route that differs significantly from previously reported routes. The key step involves a latent thioester that initiates a chemoselective transformation similar to native chemical ligation to form the
