1146468-69-0Relevant articles and documents
Facile synthesis of saikosaponins
Mu, Tong,Wang, Ziqiang,Wei, Bingcheng,Xu, Peng,Yu, Biao
, (2021)
Saikosaponin A (SSa) and D (SSd) are typical oleanane-type saponins featuring a unique 13,28-epoxy-ether moiety at D ring of the aglycones, which exhibit a wide range of biological and pharmacological activities. Herein, we report the first synthesis of saikosaponin A/D (1–2) and their natural congeners, including prosaikosaponin F (3), G (4), saikosaponin Y (5), prosaikogenin (6), and clinoposaponin I (7). The present synthesis features ready preparation of the aglycones of high oxidation state from oleanolic acid, regioselective glycosylation to construct the β-(1→3)-linked disaccharide fragment, and efficient gold(I)-catalyzed glycosylation to install the glycans on to the aglycones.
Building Units of Oligosaccharides, CIII. - Synthesis of Modified Derivatives of the Disaccharide β-D-Gal-(1->3)-α-D-GalNAc for the Examination of Substrate Specifities of Core 2-β6-GlcNAc-Transferase and α-3-Sialyltransferase Involved in the Biosynthesis
Paulsen, Hans,Rutz, Volker,Brockhausen, Inka
, p. 747 - 758 (2007/10/02)
Derivatives of benzyl β-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-α-D-galactopyranoside have been synthesized.The 6'-, 4'- and 3'-OH group of the galactose moiety as well as the 6- and 4-OH and the 2-acetamido group of the 2-acetamido-2-deoxy-D-galact