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114653-02-0

[4-(Tetrahydro-pyran-2-yloxy)-phenyl]-acetic acid (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 114653-02-0 Structure

  • Basic information

    1. Product Name: [4-(Tetrahydro-pyran-2-yloxy)-phenyl]-acetic acid (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester
    2. Synonyms:
    3. CAS NO:114653-02-0
    4. Molecular Formula:
    5. Molecular Weight: 372.505
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 114653-02-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [4-(Tetrahydro-pyran-2-yloxy)-phenyl]-acetic acid (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: [4-(Tetrahydro-pyran-2-yloxy)-phenyl]-acetic acid (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester(114653-02-0)
    11. EPA Substance Registry System: [4-(Tetrahydro-pyran-2-yloxy)-phenyl]-acetic acid (1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester(114653-02-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 114653-02-0(Hazardous Substances Data)

114653-02-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 114653-02-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,6,5 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 114653-02:
(8*1)+(7*1)+(6*4)+(5*6)+(4*5)+(3*3)+(2*0)+(1*2)=100
100 % 10 = 0
So 114653-02-0 is a valid CAS Registry Number.

114653-02-0Relevant articles and documents

Soft Drugs. 7. Soft β-Blockers for Systemic and Ophthalmic Use

Bodor, Nicholas,El-Koussi, Alaaeldin A.,Kano, Masanobu,Khalifa, Mohamed M.

, p. 1651 - 1656 (2007/10/02)

The "inactive metabolite approach" used to design a series of "soft" drugs derived from the acidic metabolite of metoprolol.Pharmacokinetic and pharmacodynamic properties of these novel "soft" β-adrenoceptor antagonists were determined: half-lives in human blood ranged from 5 to 754 min.The rates of in vivo disappearance of representative slow, medium, and fast hydrolyzing esters were determined in rats.In each case rapid and quantitative conversion to the corresponding free acid was observed.This suggests a facile, one-step degradation to the predicted major metabolite.The compounds were tested for their ability to decrease intraocular pressure in a rabbit model.Five of the new compounds exerted an ocular hypotensive action comparable to or greater than of the reference compound, timolol maleate, and with a prolonged duration of action in some cases.In contrast the new compounds showed reduced and shorter duration systemic activity.The adamantylethyl ester emerges as a potentially effective antiglaucoma agent with significantly improved site-specific activity.

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