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464-45-9 Usage

Description

Borneol is an analgetic, antibacterial, and resuscitation-inducing norborneol derived from fresh branches and leaves of Cinnamomum camphora (L.) Presl. Far more than 2000?years ago, it has been introduced to China . In China, it has been firstly recorded in Ming Yi Bie Lu and then included in Tang Ben Cao. It was recorded in history that borneol was derived from Dryobalanops camphora gaertner and then precipitated from the resin to form the natural crystal compound or distilled from the trunk and cooled down to form the crystal compound, which is certified from Indonesia. In China, the natural borneol mainly relied on imports. In recent years, it was extracted from the Lauraceae plants, including Cinnamomum camphora, Cinnamomum longepaniculatum, and Cinnamomum burmannii, which greatlyincreases the resources of natural borneol for China. Cinnamomum camphora is mainly distributed in Jiangxi and Fujian provinces with 81.78% of borneol. Cinnamomum longepaniculatum is mainly distributed in Hunan and Sichuan provinces with 77.57% of borneol. Cinnamomum burmannii is mainly distributed in Yunnan and Guangxi provinces with 70.81% of borneol. Among them, Cinnamomum camphora contains more borneol than the other two types .

Chemical Properties

white to light yellow crystalline powder or

Physical properties

Appearance: colorless to white lumps. Odor: pungent, camphor-like. Density:1.011?g/ cm3 (20?°C). Melting point: 208?°C (406?°F; 481?K). Boiling point: 213?°C (415?°F; 486?K). Solubility: slightly soluble in water (D-form), soluble in chloroform, ethanol, acetone, ether, benzene, toluene, decalin, and tetralin. Flash point: 65? °C (149?°F; 338?K). It’s stable under sealed condition while volatile in the air.

History

Borneol has been widely used worldwide. It has been systematically studied since 1803 in Dutch literature. This might be because borneol was originated from Indonesia which had been the colony of the Netherlands since the seventeenth century. Stockman reviewed the borneol systematically and conducted the preliminary pharmacological experiments. The current pharmacological studies of borneol focus on crossing blood-brain barrier and its mechanism, as well as promoting the penetration of blood-brain barrier after compatibility with other drugs, which has been started by Qizhong Mo in Shanghai Institute of Materia Medica, Chinese Academy of Sciences since 1982 . Qide Wu et al. synthesized a series of ester derivatives of natural borneol and studied its biological properties. It was found that (+) – 4-methoxybenzoic acid borneol ester had a significant effect on the opening of the blood-brain barrier and was less toxic than borneol . Because of the unique chemical structure of borneol and relatively low molecular weight, borneol is often modified to observe whether the drug has such pharmacological effects of antitumor, increasing the penetration of blood-brain barrier, antibacterial, antioxidant, and others. Up to date, there is no druggability report based on borneol modification.

Uses

Different sources of media describe the Uses of 464-45-9 differently. You can refer to the following data:
1. (-)-Borneol is used to prepare its esters by reacting with acids. Its derivatives are used as chiral ligands in asymmetric synthesis. It is also used in flavors and perfumes. Further, it is used in traditional Chinese medicine as moxa. In addition to this, it is used as a component of many essential oils and also used as a natural insect repellent.
2. (-)-Borneol has been used to study its antiapoptotic, antioxidative and neuroprotective effect in human neuroblastoma cells (SH-SY5Y).

Indications

The main efficacy of borneol is to induce resuscitation (with aromatic stimulation), clear stagnated fire (fever feeling), remove nebula for improving eyesight, and relieve swelling and pain. The indications of borneol are sore throat, aphthous, red eyes, purulent ear discharge, convulsions, febrile delirium, sudden faint due to qi depression, stroke, and coma. In Chinese traditional medicine, the borneol is often used as an envoy drug and combined with other drugs but is not used as a single medicine with the inexact efficacy

General Description

(-)-Borneol is an enantiomer. It is a bicyclic monoterpene compound used gengrally for analgesia and anaesthesia. It is considered as positive modulators of GABA receptors.

Flammability and Explosibility

Flammable

Pharmacology

The main pharmacological effects of borneol include anti-inflammatory, antibacterial, central nervous system, and antifertility effects . Guangchi Jiang found that intraperitoneal injection of borneol at 3.5 mL/kg can significantly inhibit foot swelling caused by egg white in rats. Borneol can inhibit and kill Staphylococcus aureus, B-type Streptococcus, and other five common cells with the minimum inhibitory concentration (MIC) of 1.0–2.0% and the lowest bactericidal concentration (MFC) of 1.5–2.0%. There was significant odinopoeia effect on the late pregnant mice after given 112 mg/kg borneol. Qide Liu et al. found that 10% borneol paraffin oil at the dose of 1 mg/kg by oral gavage can significantly increase the concentration of gentamicin in rat brain tissue, suggesting that borneol can change the blood-brain barrier permeability. The current mechanisms of anti-inflammatory effects include inhibition of inflammatory factors of interleukin-1β, tumor necrosis factor-α, and cell adhesion molecule-1 expression. The mechanisms of central nervous system effects are involved in inhibiting p-glycoprotein, opening the intercellular tight junction, increasing the number of pinocytotic vesicles, and improving the phospholipid molecule arrangement of epithelial cell membrane. In addition, borneol also affects the level of nitric oxide and inhibits the elevation of Ca2+ concentration.

Clinical Use

As a traditional Chinese medicine, borneol is commonly used as envoy drugs in the compatibility of traditional Chinese medicine. On behalf of combination drugs such as Danshen dripping pills, Niu Huang Jie Du pills, and watermelon cream, its effect is significant because of its special aromatic smell. Borneol with a certain irritation, oral administration may cause the gastrointestinal discomforts, severely causes vomiting and other adverse reactions.

Safety Profile

Mddly toxic by ingestion. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes. See also ALCOHOLS.

Check Digit Verification of cas no

The CAS Registry Mumber 464-45-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 464-45:
(5*4)+(4*6)+(3*4)+(2*4)+(1*5)=69
69 % 10 = 9
So 464-45-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3/t7?,8-,10+/m0/s1

464-45-9 Well-known Company Product Price

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  • Detail
  • TCI America

  • (B1012)  (-)-Borneol  >95.0%(GC)

  • 464-45-9

  • 25g

  • 250.00CNY

  • Detail
  • TCI America

  • (B1012)  (-)-Borneol  >95.0%(GC)

  • 464-45-9

  • 500g

  • 2,170.00CNY

  • Detail
  • Alfa Aesar

  • (A12684)  (-)-Borneol, 97+%   

  • 464-45-9

  • 50g

  • 292.0CNY

  • Detail
  • Alfa Aesar

  • (A12684)  (-)-Borneol, 97+%   

  • 464-45-9

  • 250g

  • 683.0CNY

  • Detail
  • Alfa Aesar

  • (A12684)  (-)-Borneol, 97+%   

  • 464-45-9

  • 1000g

  • 2412.0CNY

  • Detail
  • Sigma-Aldrich

  • (15598)  (−)-Borneol  analytical standard

  • 464-45-9

  • 15598-1G

  • 456.30CNY

  • Detail
  • Sigma-Aldrich

  • (15598)  (−)-Borneol  analytical standard

  • 464-45-9

  • 15598-5G

  • 904.41CNY

  • Detail
  • Aldrich

  • (139114)  (−)-Borneol  predominantly endo, 97%

  • 464-45-9

  • 139114-100G

  • 1,209.78CNY

  • Detail
  • Aldrich

  • (139114)  (−)-Borneol  predominantly endo, 97%

  • 464-45-9

  • 139114-500G

  • 5,613.66CNY

  • Detail

464-45-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (-)-borneol

1.2 Other means of identification

Product number -
Other names L-BORNEOL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:464-45-9 SDS

464-45-9Synthetic route

bornyl trimethylsilyl ether
88390-69-6

bornyl trimethylsilyl ether

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With methanol; 1,3-disulfonic acid imidazolium hydrogen sulfate at 20℃; for 0.0833333h; Green chemistry;96%
(1S)-camphor
464-48-2

(1S)-camphor

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With trans-bis(triphenylphosphine)palladium dichloride; dibutyltin In methanol at 25℃; for 3h; Inert atmosphere;96%
tert-Butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-((1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yloxy)-silane

tert-Butyl-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyloxy)-phenyl-((1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yloxy)-silane

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 3h; deprotection;94%
L-bornyl p-toluenesulfonate
20053-48-9

L-bornyl p-toluenesulfonate

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With magnesium In methanol for 6h; Ambient temperature;90%
3-Heptadecafluorooctyl-2-((1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yloxy)-tetrahydro-pyran

3-Heptadecafluorooctyl-2-((1S,2R,4S)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yloxy)-tetrahydro-pyran

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With methanol; toluene-4-sulfonic acid In tetrahydrofuran at 70℃; for 24h; deprotection of alcoholic OH;88%
(1S,2R,4S)-2-(4-Methoxy-benzyloxy)-1,7,7-trimethyl-bicyclo[2.2.1]heptane
54384-77-9

(1S,2R,4S)-2-(4-Methoxy-benzyloxy)-1,7,7-trimethyl-bicyclo[2.2.1]heptane

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; sodium cyanoborohydride In tetrahydrofuran for 12h; Heating;85%
<2(R)-(1-bornyloxy)-5,6-dihydro-2H-pyran-5(R)-yl>acetic acid
100703-54-6

<2(R)-(1-bornyloxy)-5,6-dihydro-2H-pyran-5(R)-yl>acetic acid

A

endo-borneol
464-45-9

endo-borneol

B

3a(S),7a(S)-dihydro-4H-furo<3,2-c>pyran-2(3H)-one
87614-57-1

3a(S),7a(S)-dihydro-4H-furo<3,2-c>pyran-2(3H)-one

Conditions
ConditionsYield
With tin(IV) chloride In dichloromethane at -78℃;A n/a
B 84%
With tin(IV) chloride; potassium carbonate; triethylamine 1.) CH2Cl2, -78 deg C, 30 min, 2.) RT, 10 min; Yield given. Multistep reaction. Yields of byproduct given;
benzyl (1S,2R,4S)-(-)-bornyl ether

benzyl (1S,2R,4S)-(-)-bornyl ether

A

endo-borneol
464-45-9

endo-borneol

B

benzoic acid
65-85-0

benzoic acid

Conditions
ConditionsYield
With bis(acetylacetonate)oxovanadium; methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate at 120℃; for 48h;A 70%
B 80%
bornyl acetate
5655-61-8

bornyl acetate

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With bis(tri-n-butyltin)oxide In acetonitrile at 90℃; for 96h;12.7%
With the cultured cells of Nicotiana tabacum at 25℃; for 240h; biotransformation of various acetates in the dark;
tetrachloromethane
56-23-5

tetrachloromethane

phthalic anhydride
85-44-9

phthalic anhydride

ethanol
64-17-5

ethanol

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
at 135 - 140℃; anschl. verseifen;
phthalic anhydride
85-44-9

phthalic anhydride

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With ethanol; xylene at 135 - 140℃; Hydrolyse des Reaktionsprodukts;
With Pinene; ethanol at 135 - 140℃; Hydrolyse des Reaktionsprodukts;
endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With dihydrogen peroxide; acetic acid at 50 - 55℃;
With acetic anhydride; acetic acid; benzenesulfonic acid
With trichloroacetic acid
(-)-α-pinene
7785-26-4

(-)-α-pinene

acetic anhydride
108-24-7

acetic anhydride

endo-borneol
464-45-9

endo-borneol

Conditions
ConditionsYield
With boron trioxide at 90 - 95℃; Hydrolyse des Reaktionsprodukts;
Conditions
ConditionsYield
With 2,2'-iminobis[ethanol]; (-)-diisopinocamphenylborane chloride Product distribution; multistep reaction: 1.) room temperature, 0.5 h, 2.) Et2O, 2 h; stereoselective reduction of α-chiral ketones with (+)- and (-)-B-chlorodiisopinocampheylboranes; diastereomeric excess; selectivity of matched and mismatched pairs; possible mechanism;
With isopropyl alcohol; zirconium(IV) oxide at 150℃; for 0.5h; Yield given. Yields of byproduct given;
With aluminum oxide; sodium; isopropyl alcohol In tetrahydrofuran for 5h; Heating;A 74.5 % Chromat.
B 25.5 % Chromat.
Conditions
ConditionsYield
With isopropyl alcohol; zirconium(IV) oxide at 200℃; for 0.5h; Yield given. Yields of byproduct given;
L-bornyl p-toluenesulfonate
20053-48-9

L-bornyl p-toluenesulfonate

A

endo-borneol
464-45-9

endo-borneol

B

(+)-camphene
79-92-5

(+)-camphene

C

(+)-bornene
18383-34-1

(+)-bornene

Conditions
ConditionsYield
With lithium; ethylamine for 24h; Heating; Title compound not separated from byproducts;A 90 % Chromat.
B 2 % Chromat.
C 8 % Chromat.
rac-endo-borneol
6627-72-1

rac-endo-borneol

A

(1S)-camphor
464-48-2

(1S)-camphor

B

endo-borneol
464-45-9

endo-borneol

C

(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
464-49-3

(1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

Conditions
ConditionsYield
at 25℃; Yield given. Yields of byproduct given;
<2(S)-(1-bornyloxy)-5,6-dihydro-2H-pyran-5(S)-yl>acetic acid
117556-75-9

<2(S)-(1-bornyloxy)-5,6-dihydro-2H-pyran-5(S)-yl>acetic acid

A

endo-borneol
464-45-9

endo-borneol

B

3a(R),7a(R)-dihydro-4H-furo<3,2-c>pyran-2(3H)-one
117556-76-0

3a(R),7a(R)-dihydro-4H-furo<3,2-c>pyran-2(3H)-one

Conditions
ConditionsYield
With tin(IV) chloride; potassium carbonate; triethylamine 1.) CH2Cl2, -78 deg C, 30 min, 2.) RT, 10 min; Yield given. Multistep reaction;
<2(S)-(1-bornyloxy)-5,6-dihydro-2H-pyran-5(R)-yl>acetic acid
117556-79-3

<2(S)-(1-bornyloxy)-5,6-dihydro-2H-pyran-5(R)-yl>acetic acid

A

endo-borneol
464-45-9

endo-borneol

B

3a(S),7a(S)-dihydro-4H-furo<3,2-c>pyran-2(3H)-one
87614-57-1

3a(S),7a(S)-dihydro-4H-furo<3,2-c>pyran-2(3H)-one

Conditions
ConditionsYield
With tin(IV) chloride; potassium carbonate; triethylamine 1.) CH2Cl2, -78 deg C, 30 min, 2.) RT, 10 min; Yield given. Multistep reaction. Yields of byproduct given;
With tin(IV) chloride In dichloromethane at -78℃;
Conditions
ConditionsYield
With (+)-β-chlorodiisopinocampheylborane; 2,2'-iminobis[ethanol] 1.) room temperature, 2 h, 2.) Et2O, 2 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
6A,6B-bis(2-naphthylsulfonyl)-γ-cyclodextrin (-)-borneol 1:1 complex

6A,6B-bis(2-naphthylsulfonyl)-γ-cyclodextrin (-)-borneol 1:1 complex

A

endo-borneol
464-45-9

endo-borneol

B

6A,6B-bis(2-naphthylsulfonyl)-γ-cyclodextrin

6A,6B-bis(2-naphthylsulfonyl)-γ-cyclodextrin

Conditions
ConditionsYield
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation;
6A,6C-bis(2-naphthylsulfonyl)-γ-cyclodextrin (-)-borneol 1:1 complex

6A,6C-bis(2-naphthylsulfonyl)-γ-cyclodextrin (-)-borneol 1:1 complex

A

endo-borneol
464-45-9

endo-borneol

B

6A,6C-bis(2-naphthylsulfonyl)-γ-cyclodextrin

6A,6C-bis(2-naphthylsulfonyl)-γ-cyclodextrin

Conditions
ConditionsYield
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation;
6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin (-)-borneol 1:1 complex

6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin (-)-borneol 1:1 complex

A

endo-borneol
464-45-9

endo-borneol

B

6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin

6A,6D-bis(2-naphthylsulfonyl)-γ-cyclodextrin

Conditions
ConditionsYield
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation;
6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin (-)-borneol 1:1 complex

6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin (-)-borneol 1:1 complex

A

endo-borneol
464-45-9

endo-borneol

B

6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin

6A,6E-bis(2-naphthylsulfonyl)-γ-cyclodextrin

Conditions
ConditionsYield
In water; ethylene glycol at 25℃; Equilibrium constant; decomplexation;
C49H76O34Se*C10H18O

C49H76O34Se*C10H18O

A

endo-borneol
464-45-9

endo-borneol

B

mono<6-(benzylseleno)-6-deoxy>-β-cyclodextrin
202332-62-5

mono<6-(benzylseleno)-6-deoxy>-β-cyclodextrin

Conditions
ConditionsYield
With phosphate buffer In water at 25℃; Equilibrium constant;
C49H76O34Se*C10H18O

C49H76O34Se*C10H18O

A

endo-borneol
464-45-9

endo-borneol

B

mono<6-(p-tolylseleno)-6-deoxy>-β-cyclodextrin
202332-61-4

mono<6-(p-tolylseleno)-6-deoxy>-β-cyclodextrin

Conditions
ConditionsYield
With phosphate buffer In water at 25℃; Equilibrium constant;
C49H76O34Se*C10H18O

C49H76O34Se*C10H18O

A

endo-borneol
464-45-9

endo-borneol

B

mono<6-(m-tolylseleno)-6-deoxy>-β-cyclodextrin
211802-10-7

mono<6-(m-tolylseleno)-6-deoxy>-β-cyclodextrin

Conditions
ConditionsYield
With phosphate buffer In water at 25℃; Equilibrium constant;
C49H76O34Se*C10H18O

C49H76O34Se*C10H18O

A

endo-borneol
464-45-9

endo-borneol

B

mono<6-(o-tolylseleno)-6-deoxy>-β-cyclodextrin
211802-08-3

mono<6-(o-tolylseleno)-6-deoxy>-β-cyclodextrin

Conditions
ConditionsYield
With phosphate buffer In water at 25℃; Equilibrium constant;

464-45-9Relevant articles and documents

Simple Plug-In Synthetic Step for the Synthesis of (?)-Camphor from Renewable Starting Materials

Calderini, Elia,Drienovská, Ivana,Myrtollari, Kamela,Pressnig, Michaela,Sieber, Volker,Schwab, Helmut,Hofer, Michael,Kourist, Robert

, p. 2951 - 2956 (2021/06/18)

Racemic camphor and isoborneol are readily available as industrial side products, whereas (1R)-camphor is available from natural sources. Optically pure (1S)-camphor, however, is much more difficult to obtain. The synthesis of racemic camphor from α-pinene proceeds via an intermediary racemic isobornyl ester, which is then hydrolyzed and oxidized to give camphor. We reasoned that enantioselective hydrolysis of isobornyl esters would give facile access to optically pure isoborneol and camphor isomers, respectively. While screening of a set of commercial lipases and esterases in the kinetic resolution of racemic monoterpenols did not lead to the identification of any enantioselective enzymes, the cephalosporin Esterase B from Burkholderia gladioli (EstB) and Esterase C (EstC) from Rhodococcus rhodochrous showed outstanding enantioselectivity (E>100) towards the butyryl esters of isoborneol, borneol and fenchol. The enantioselectivity was higher with increasing chain length of the acyl moiety of the substrate. The kinetic resolution of isobornyl butyrate can be easily integrated into the production of camphor from α-pinene and thus allows the facile synthesis of optically pure monoterpenols from a renewable side-product.

Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process

Baev, Dmitriy S.,Maksyutov, Rinat A.,Mordvinova, Ekaterina D.,Pyankov, Oleg V.,Salakhutdinov, Nariman F.,Shcherbakov, Dmitriy N.,Shcherbakova, Nadezhda S.,Sokolova, Anastasiya S.,Tolstikova, Tatyana G.,Yarovaya, Olga I.,Zaykovskaya, Anna V.,Zybkina, Anastasiya V.

, (2020/09/09)

In this study, we screened a large library of (+)-camphor and (?)-borneol derivatives to assess their filovirus entry inhibition activities using pseudotype systems. Structure-activity relationship studies revealed several compounds exhibiting submicromolar IC50 values. These compounds were evaluated for their effect against natural Ebola virus (EBOV) and Marburg virus. Compound 3b (As-358) exhibited the good antiviral potency (IC50 = 3.7 μM, SI = 118) against Marburg virus, while the hydrochloride salt of this compound 3b·HCl had a strong inhibitory effect against Ebola virus (IC50 = 9.1 μM, SI = 31) and good in vivo safety (LD50 > 1000 mg/kg). The results of molecular docking and in vitro mutagenesis analyses suggest that the synthesized compounds bind to the active binding site of EBOV glycoprotein similar to the known inhibitor toremifene.

Synthesis method of levo-borneol

-

Paragraph 0036; 0039-0041; 0044-0046; 0049-0051; 0054-0055, (2020/09/02)

The invention relates to a synthetic method of L-borneol. The method comprises: reducing di-n-butyltin dichloride to obtain di-n-butyltin dihydride via lithium aluminium hydride, performing a reactionamong 2-camphanone, palladium bis(triphenylphosphine) dichloride and methanol, adding di-n-butyltin dihydride drop by drop while performing uniform stirring, performing a reaction at the room temperature for 1 h, after the reaction is over, performing pressure-reduction rotary evaporation to remove methanol, and performing separation to obtain L-borneol, which is the target compound.

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