114657-02-2Relevant academic research and scientific papers
Reduction of 5-arylidenebarbiturate derivatives by thiols
Meissner,Van Der Laan,Pandit
, p. 2757 - 2760 (2007/10/02)
The electrophilic olefin function of 5-arylidenebarbiturates is reduced by thiols in the presence of triethylamine. Mechanistic aspects of the reaction are discussed.
OXIDATION OF THIOL WITH 5-ARYLIDENE-1,3-DIMETHYLBARBITURIC ACID: APPLICATION TO SYNTHESIS OF UNSYMMETRICAL DISULFIDE
Tanaka, Kiyoshi,Chen, Xing,Yoneda, Fumio
, p. 3241 - 3250 (2007/10/02)
5-Arylidene-1,3-dimethylbarbituric acid derivatives, such as 1a and 1b, effectively oxidized both alkane- and benzenethiols to disulfides under neutral condition with concomitant formation of the dihydro compounds (2a) and (2b).Thiol adduct of the dihydro compound was prepared as a stable compound and successfully applied to the synthesis of unsymmetrical disulfide under mild condition in excellent yield.Mechanistic consideration for the oxidation was also described briefly.
OXIDATION OF THIOL BY 5-ARYLIDENE 1,3-DIMETHYLBARBITURIC ACID AND ITS APPLICATION TO SYNTHESIS OF UNSYMMETRICAL DISULFIDE
Tanaka, Kiyoshi,Chen, Xing,Kimura, Teiji,Yoneda, Fumio
, p. 4173 - 4176 (2007/10/02)
Oxidation of both aromatic and aliphatic thiols by 5-arylidene 1,3-dimethylbarbituric acid was found to proceed readily to give disulfides in good yield with concomitant reduction of the oxidant to the dihydro compound.Thiol adduct of the dihydro compound was succesfully applied to the synthesis of unsymmetrical disulfide under mild conditions in an excellent yield.
