114657-07-7

Usage

Molecular weight

338.41 g/mol

Type of compound

Thiobarbituric acid derivative of barbituric acid

Biological activity

Central nervous system depressant

Common use

Building block in organic synthesis and pharmaceutical research

Structural features

Presence of a phenyl and a methoxybenzyl group

Pharmacological properties

Influenced by the phenyl and methoxybenzyl groups

Potential applications

Medicinal applications due to unique molecular structure

Research interest

Subject of interest in medicinal chemistry and drug development research

Upstream product

• 108-98-5 thiophenol 
• 114657-04-4 5-chloro-1,3-dimethyl-5-(4'-methoxybenzyl)barbituric acid 
• 114656-99-4 5-(4-methoxybenzyl)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione 
• 931-59-9 benzenesulfenyl chloride 
• 114657-01-1 5-(n-butylthio)-1,3-dimethyl-5-(4'-methoxybenzyl)barbituric acid 

Downstream Products

• 20129-23-1 butyl phenyl disulfide 
• 882-33-7 diphenyldisulfane 
• 114656-99-4 5-(4-methoxybenzyl)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione 
• 16601-17-5 phenyl phenylmethyl disulfide 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 33965-85-4 1-(4-chlorophenyl)-2-phenyldisulfane 

Relevant academic research and scientific papers

OXIDATION OF THIOL WITH 5-ARYLIDENE-1,3-DIMETHYLBARBITURIC ACID: APPLICATION TO SYNTHESIS OF UNSYMMETRICAL DISULFIDE

5-Arylidene-1,3-dimethylbarbituric acid derivatives, such as 1a and 1b, effectively oxidized both alkane- and benzenethiols to disulfides under neutral condition with concomitant formation of the dihydro compounds (2a) and (2b).Thiol adduct of the dihydro compound was prepared as a stable compound and successfully applied to the synthesis of unsymmetrical disulfide under mild condition in excellent yield.Mechanistic consideration for the oxidation was also described briefly.

OXIDATION OF THIOL BY 5-ARYLIDENE 1,3-DIMETHYLBARBITURIC ACID AND ITS APPLICATION TO SYNTHESIS OF UNSYMMETRICAL DISULFIDE

Oxidation of both aromatic and aliphatic thiols by 5-arylidene 1,3-dimethylbarbituric acid was found to proceed readily to give disulfides in good yield with concomitant reduction of the oxidant to the dihydro compound.Thiol adduct of the dihydro compound was succesfully applied to the synthesis of unsymmetrical disulfide under mild conditions in an excellent yield.