114656-99-4

Upstream product

• 109-79-5 n-butanethiol 
• 114657-07-7 1,3-dimethyl-5-(4'-methoxybenzyl)-5-phenylthiobarbituric acid 
• 57270-82-3 5-(4-methoxy-benzylidene)-1,3-dimethyl-pyrimidine-2,4,6-trione 
• 106-54-7 p-Chlorothiophenol 
• 114657-01-1 5-(n-butylthio)-1,3-dimethyl-5-(4'-methoxybenzyl)barbituric acid 
• 100-53-8 phenylmethanethiol 
• 108-98-5 thiophenol 

Downstream Products

• 114657-04-4 5-chloro-1,3-dimethyl-5-(4'-methoxybenzyl)barbituric acid 
• 114657-07-7 1,3-dimethyl-5-(4'-methoxybenzyl)-5-phenylthiobarbituric acid 
• 57270-82-3 5-(4-methoxy-benzylidene)-1,3-dimethyl-pyrimidine-2,4,6-trione 
• 114657-01-1 5-(n-butylthio)-1,3-dimethyl-5-(4'-methoxybenzyl)barbituric acid 
• 150-60-7 dibenzyl disulphide 

Relevant academic research and scientific papers

Peculiar reaction behaviour of barbituric acid derivatives towards aromatic amines

5-Benzoylethyl barbituric acid derivatives 2a-c were prepared as useful precursors for the synthesis of pyrimidine fused heterocycles. Their behaviour as 1,5-diketocompounds towards aniline derivatives afforded the pyrimidoquinoline derivatives 6a-e. On t

Unusual Reaction Constant for Hydride Transfer from a Carbanion to 9-Arylxanthyliums

The reaction constant (ρ) from the kinetics for hydride transfer from a carbanion (XH-) to 9-arylxanthylium ions (9-GPhXn+) in CH3CN was unusually negative. Thermodynamic analysis indicated that ρ for the simple hydride tr

B(C6F5)3-Catalyzed transfer 1,4-hydrostannylation of α,β-unsaturated carbonyls using iPr-tricarbastannatrane

Tris(pentafluorophenyl)borane, B(C6F5)3, has been found to be an effective catalyst to access the hydridoborate anion, [N(CH2CH2CH2)3Sn][HB(C6F5)3/sub

N-HYDROXYLAMINO-BARBITURIC ACID DERIVATIVES AS NITROXYL DONORS

The present disclosure provides N-hydroxylamino-barbituric acid compounds of formulae (1)- (4), pharmaceutical compositions and kits comprising them, and methods of using such compounds or pharmaceutical compositions. The present disclosure provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Mechanism of hydride transfer reaction from β-substituted carbanions to a carbocation

Mechanism of hydride transfer reactions to form olefins is still a conundrum. Here, we propose an electron transfer (ET) followed by hydrogen atom transfer (HT) as the most likely mechanism for hydride transfer reactions from the hydride adducts of olefins (G-XH-) to a carbocation (T+) in acetonitrile. This is confirmed by the analysis of the energetics of each mechanistic step, estimated from ΔHH - (the hydride affinity) and redox potentials of the related species, and activation energetics calculated from rate constants of the hydride transfer from G-XH- to T+.

Mono C-alkylation and mono C-benzylation of barbituric acids through zinc/acid reduction of acyl, benzylidene, and alkylidene barbiturate intermediates

Through systematic exploration of reaction conditions, very efficient preparative procedures for obtaining large quantities of substituted 5-alkyl and 5-benzylbarbituric acids were developed. The procedure involves a two step preparation in which the second step is zinc dust/acid reduction. For preparation of 5-alkylbarbiturates, the first step is the preparation of either 5-acyl or 5-alkylidenebarbiturate. If 5-benzylbarbiturate is the target product, then the first step includes the preparation of 5-benzylidene. Regardless of the nature of the first step, all reactions presented synthetic yields around 90% and isolation and purification involves only crystallization.

Reductive C-alkylation of barbituric acid derivatives with carbonyl compounds in the presence of platinum and palladium catalysts

Effective synthetic procedures for the preparation of mono- and di-C-alkylated barbituric acid derivatives through palladium and platinum catalytic hydrogenation of solutions of barbituric acids (unsubstituted, N-mono, and N,N′-disubstituted barbituric acids) and carbonyl compounds (aliphatic and aromatic aldehydes and ketones).

Chemical modification of plant alkaloids. I. Aminomethylation of barbituric acid derivatives by cytisine

Reaction of cytisine with 1-mono-and 1,3-disubstituted 5-arylmethylbarbituric acids in the presence of formaldehyde results in aminomethylation of C-5 to form the corresponding 5-cytisylmethylbarbituric acids. The structures of the products are found usin

Reduction of 5-arylidenebarbiturate derivatives by thiols

The electrophilic olefin function of 5-arylidenebarbiturates is reduced by thiols in the presence of triethylamine. Mechanistic aspects of the reaction are discussed.

OXIDATION OF THIOL WITH 5-ARYLIDENE-1,3-DIMETHYLBARBITURIC ACID: APPLICATION TO SYNTHESIS OF UNSYMMETRICAL DISULFIDE

5-Arylidene-1,3-dimethylbarbituric acid derivatives, such as 1a and 1b, effectively oxidized both alkane- and benzenethiols to disulfides under neutral condition with concomitant formation of the dihydro compounds (2a) and (2b).Thiol adduct of the dihydro compound was prepared as a stable compound and successfully applied to the synthesis of unsymmetrical disulfide under mild condition in excellent yield.Mechanistic consideration for the oxidation was also described briefly.