1146615-89-5

Basic information

• Product Name: 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester
• Synonyms: 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester;2-Chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;Pyridine, 2-chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
• CAS NO: 1146615-89-5
• Molecular Formula: C₁₁H₁₄BClFNO₂
• Molecular Weight: 257.5
• Mol File: 1146615-89-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 344.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.16±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester(1146615-89-5)
• EPA Substance Registry System: 2-Chloro-6-fluoropyridine-4-boronic acid,pinacol ester(1146615-89-5)

Safety Data

• Hazardous Substances Data: 1146615-89-5(Hazardous Substances Data)

Usage

Uses

2-Chloro-6-fluoropyridine-4-boronic acid, pinacol ester

Upstream product

• 20885-12-5 2-chloro-6-fluoropyridine 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

C-H Borylation Catalysts that Distinguish between Similarly Sized Substituents like Fluorine and Hydrogen

By modifying ligand steric and electronic profiles it is possible to C-H borylate ortho or meta to substituents in aromatic and heteroaromatic compounds, where steric differences between accessible C-H sites are small. Dramatic effects on selectivities between reactions using B2pin2 or 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (HBpin) are described for the first time. Judicious ligand and borane combinations give highly regioselective C-H borylations on substrates where typical borylation protocols afford poor selectivities.