114667-07-1

Upstream product

• 626-61-9 4-Chloropyridine 
• 122376-75-4 (4-Fluoro-phenyl)-pyridin-4-yl-acetonitrile 
• 914386-20-2 (Z)-3-(4-Fluoro-phenyl)-3-(4-methoxy-phenyl)-acrylonitrile 
• 459-22-3 4-fluorophenylacetonitrile 
• 122376-63-0 Ethyl-4-cyan-4-(4-fluorphenyl)-4-(4-pyridinyl)butanoat 
• 122376-64-1 4-(4-Fluorphenyl)-4-(4-pyridinyl)butansaeure 

Relevant academic research and scientific papers

Soluble Epoxide Hydrolase Inhibitors and Methods of Using Same

Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.

Synthesis of Primary ω-Phenyl-ω-pyridylalkylamines

Phthalimidoalkylation of phenylpyridylacetonitriles followed by acidic or basic hydrolysis and decarboxylation is a convenient method for the preparation of pheniramine-like primary amines.Substituted dihydropyrrolamines were isolated as intermediates in the synthesis of the corresponding propylamines.Alternatively, 3,3-diarylpropylamines were prepared via Horner-Emmons reaction of pertinent ketones with diethyl cyanomethanephosphonate followed by reduction with complex hydrides.