122376-75-4

Upstream product

• 626-61-9 4-Chloropyridine 
• 459-22-3 4-fluorophenylacetonitrile 

Downstream Products

• 122376-63-0 Ethyl-4-cyan-4-(4-fluorphenyl)-4-(4-pyridinyl)butanoat 
• 114667-07-1 3-(4-Fluorphenyl)-3-(4-pyridinyl)propanamin 
• 122376-64-1 4-(4-Fluorphenyl)-4-(4-pyridinyl)butansaeure 

Relevant academic research and scientific papers

Synthesis of Primary ω-Phenyl-ω-pyridylalkylamines

Phthalimidoalkylation of phenylpyridylacetonitriles followed by acidic or basic hydrolysis and decarboxylation is a convenient method for the preparation of pheniramine-like primary amines.Substituted dihydropyrrolamines were isolated as intermediates in the synthesis of the corresponding propylamines.Alternatively, 3,3-diarylpropylamines were prepared via Horner-Emmons reaction of pertinent ketones with diethyl cyanomethanephosphonate followed by reduction with complex hydrides.