114671-88-4

Basic information

• Product Name: ethyl 1-(benzyloxymethyl)cyclobutanecarboxylate
• Synonyms: ethyl 1-(benzyloxymethyl)cyclobutanecarboxylate
• CAS NO: 114671-88-4
• Molecular Weight: 248.322
• Mol File: 114671-88-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 1-(benzyloxymethyl)cyclobutanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-(benzyloxymethyl)cyclobutanecarboxylate(114671-88-4)
• EPA Substance Registry System: ethyl 1-(benzyloxymethyl)cyclobutanecarboxylate(114671-88-4)

Safety Data

• Hazardous Substances Data: 114671-88-4(Hazardous Substances Data)

Upstream product

• 1195-81-9 ethyl 1-(hydroxymethyl)cyclobutanecarboxylate 
• 4257-83-4 benzyl 2,2,2-trichloroacetamide 
• 3779-29-1 diethyl cyclobutane-1,1-dicarboxylate 

Downstream Products

• 1610456-25-1 1-((benzyloxy)methyl)-N-(4-cyano-2,3,5,6-tetrafluorophenyl)-2-phenylcyclobutanecarboxamide 
• 1610455-69-0 1-((benzyloxy)methyl)-N-(4-cyano-2,3,5,6-tetrafluorophenyl)cyclobutanecarboxamide 
• 1387563-26-9 C₁₃H₁₆O₃ 
• 1610455-66-7 C₁₃H₁₅ClO₂ 

Relevant articles and documents

Palladium(II)-catalyzed enantioselective C(sp3)-H activation using a chiral hydroxamic acid ligand

An enantioselective method for Pd(II)-catalyzed cross-coupling of methylene β-C(sp3)-H bonds in cyclobutanecarboxylic acid derivatives with arylboron reagents is described. High yields and enantioselectivities were achieved through the development of chiral mono-N-protected α-amino-O- methylhydroxamic acid (MPAHA) ligands, which form a chiral complex with the Pd(II) center. This reaction provides an alternative approach to the enantioselective synthesis of cyclobutanecarboxylates containing α-chiral quaternary stereocenters. This new class of chiral catalysts also show promises for enantioselective β-C(sp3)-H activation of acyclic amides.