1610455-69-0Relevant articles and documents
Palladium(II)-catalyzed enantioselective C(sp3)-H activation using a chiral hydroxamic acid ligand
Xiao, Kai-Jiong,Lin, David W.,Miura, Motofumi,Zhu, Ru-Yi,Gong, Wei,Wasa, Masayuki,Yu, Jin-Quan
, p. 8138 - 8142 (2014/06/23)
An enantioselective method for Pd(II)-catalyzed cross-coupling of methylene β-C(sp3)-H bonds in cyclobutanecarboxylic acid derivatives with arylboron reagents is described. High yields and enantioselectivities were achieved through the development of chiral mono-N-protected α-amino-O- methylhydroxamic acid (MPAHA) ligands, which form a chiral complex with the Pd(II) center. This reaction provides an alternative approach to the enantioselective synthesis of cyclobutanecarboxylates containing α-chiral quaternary stereocenters. This new class of chiral catalysts also show promises for enantioselective β-C(sp3)-H activation of acyclic amides.