1146969-04-1

Basic information

• Product Name: diethyl 5-formyl-4-(2-methoxyphenyl)furan-2,3-dicarboxylate
• Synonyms: diethyl 5-formyl-4-(2-methoxyphenyl)furan-2,3-dicarboxylate
• CAS NO: 1146969-04-1
• Molecular Weight: 346.337
• Mol File: 1146969-04-1.mol

Chemical Properties

• CAS DataBase Reference: diethyl 5-formyl-4-(2-methoxyphenyl)furan-2,3-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 5-formyl-4-(2-methoxyphenyl)furan-2,3-dicarboxylate(1146969-04-1)
• EPA Substance Registry System: diethyl 5-formyl-4-(2-methoxyphenyl)furan-2,3-dicarboxylate(1146969-04-1)

Safety Data

• Hazardous Substances Data: 1146969-04-1(Hazardous Substances Data)

Upstream product

• 154884-62-5 3-(2-methoxyphenyl)propargyl alcohol 
• 529-28-2 4-iodoanisol 
• 1146968-99-1 diethyl 5-formylfuran-2,3-dicarboxylate 

Relevant articles and documents

Copper-Catalyzed domino rearrangement/dehydrogenation oxidation/carbene Oxidation for One-Pot regiospecific synthesis of highly functionalized polysubstituted furans

A novel and efficient method for the regiospecific synthesis of polysubstituted furan aldehydes/ketones has been developed via a coppers-catalyzed rearrangement/dehydrogenation oxidation/carbene oxidation sequence of 1,5-enynes in situ formed from alkynol

Ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C-H bond cleavages

A variety of functionalized furans were synthesized by way of a ruthenium-catalyzed coupling reaction of 2,3,5-trisubstituted furans with aryl halides through C-H bond cleavages. The feature of the reaction was facilitative preparation of furan derivative

Transition-metal-catalyzed domino reactions: Efficient one-pot regiospecific synthesis of highly functionalized polysubstituted furans from electron-deficient alkynes and 2-Yn-1-ols

Based on the reactive behavior of different transition-metal catalysts, three methods for the synthesis of highly functionalized polysubstituted furan derivatives are presented: (i) copper(I) iodide catalyzed regiospecific synthesis of furan aldehydes/ketones from alkynols and diethyl but-2-ynedioate under atmospheric pressure; (ii) nano-Cu-catalyzed domino process for the regioselective synthesis of -carbonylfurans from readily accessible starting materials; (iii) silver-catalyzed one-pot cyclization in toluene at 50 C for the synthesis of furan derivatives. It was notably that all the domino reactions were smooth under mild conditions with commercially available catalysts, and afforded highly functionalized furans in moderate to good yields. As we know, furans derivatives are extremely useful organic molecules used as synthetic building blocks for the synthesis of more elaborate heterocyclic compounds. Georg Thieme Verlag Stuttgart.

Nano-Cu2O-catalyzed formation of C-C and C-O bonds: One-pot domino process for regioselective synthesis of α-carbonyl furans from electron-deficient alkynes and 2-Yn-1-ols

The formation of carboncarbon and carbon-oxygen bonds continues to be an active and challenging field of chemical research. Nanoparticle catalysis has attracted considerable attention owing to its environmentally benign and high activity toward the reactions. Herein, we described a novel and effective nano-Cu2O-catalyzed one-pot domino process for the regioselective synthesis of α-carbonyl furans. Various electron-deficient alkynes with 2-yn-1-ols underwent this process smoothly in moderate to good yields in the presence of air at atmospheric pressure. It is especially noteworthy that a novel 2,4,5-trisubstituted 3-ynylfuran was formed in an extremely direct manner without tedious stepwise synthesis. Additionally, as all of the starting materials are readily available, this method may allow the synthesis of more complex α-carbonyl furans. An experiment to elucidate the mechanism suggested that the process involved a carbene intermediate.