1146970-01-5Relevant academic research and scientific papers
Design and synthesis of reboxetine analogs morpholine derivatives as selective norepinephrine reuptake inhibitors
Xu, Wenjian,Gray, David L.,Glase, Shelly A.,Barta, Nancy S.
scheme or table, p. 5550 - 5553 (2009/05/30)
As part of a discovery effort aimed at identifying novel norepinephrine reuptake inhibitors (NRIs), a number of substituted morpholines were designed and synthesized. The target compounds contain vicinal stereogenic centers, and the program was greatly facilitated by the adoption of efficient synthetic routes which allowed for the late stage incorporation of structural and physicochemical diversity into the targets. Structure-activity relationships were developed by optimizing individual ring components of the structure for NRI potency and for selectivity against other monoamine reuptake transporters. Several novel morpholine derivatives with a potent and selective NRI profile are described.
Substituted morpholine compounds for the treatment of central nervous system disorders
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Page/Page column 45, (2010/02/14)
This invention relates to compounds of the formulae I wherein R1-R8, A, X, and Z are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.
