27489-33-4

Basic information

• Product Name: 2-(METHYLSULFONYL)PHENOL
• Synonyms: 2-(Methylsulphonyl)phenol;2-(Methylsulphonyl)phenol 98%;2-METHANESULPHONYLPHENOL;2-Hydroxyphenyl methyl sulphone;2-(Methylsulphonyl)phenol98%;2-(METHYLSULFONYL)BENZENOL;2-(METHYLSULFONYL)PHENOL
• CAS NO: 27489-33-4
• Molecular Formula: C₇H₈O₃S
• Molecular Weight: 172.2
• Product Categories: blocks;BuildingBlocks
• Mol File: 27489-33-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 78-84
• Boiling Point: 358.8 °C at 760 mmHg
• Flash Point: 170.8 °C
• Appearance: /
• Density: 1.328 g/cm³
• Vapor Pressure: 1.2E-05mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: 2-8°C
• PKA: 6.83±0.30(Predicted)
• CAS DataBase Reference: 2-(METHYLSULFONYL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLSULFONYL)PHENOL(27489-33-4)
• EPA Substance Registry System: 2-(METHYLSULFONYL)PHENOL(27489-33-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 27489-33-4(Hazardous Substances Data)

Usage

General Description

2-(Methylsulfonyl)phenol is a chemical compound with the molecular formula C7H8O3S. It is a white crystalline solid that is soluble in water and most organic solvents. This chemical is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals, as well as in the synthesis of other organic compounds. It is also used as a versatile building block in the manufacturing of dyes, pigments, and polymer additives. Additionally, 2-(Methylsulfonyl)phenol is utilized in the production of fragrances and flavorings. However, it is important to handle and use this chemical with care, as it can cause irritation to the skin, eyes, and respiratory system if proper safety precautions are not followed.

InChI:InChI=1/C7H8O3S/c1-11(9,10)7-5-3-2-4-6(7)8/h2-5,8H,1H3

Upstream product

• 13736-79-3 1-methanesulfonyl-2-methoxy-benzene 
• 654-47-7 1-fluoro-2-(methylsulfonyl)benzene 
• 1073-29-6 2-(methylsulfenyl)phenol 

Downstream Products

• 849465-13-0 (R)-2-(2-methanesulfonyl-phenoxymethyl)-oxirane 
• 1018672-08-6 C₁₅H₁₃N₃O₃S 
• 1146340-65-9 C₁₈H₁₅N₃O₆S₂ 
• 1017782-54-5 2-(2-(methylsulfonyl)phenoxy)acetic acid 
• 1616075-03-6 N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-(2-(methylsulfonyl)phenoxy)acetamide 
• 1610951-81-9 3-(1-(4-chlorophenyl)cyclopropyl)-8-(2-(methylsulfonyl)phenoxy)-[1,2,4]triazolo[4,3-a]pyridine 
• 1616059-38-1 N-(2-hydroxy-3-(isoindolin-2-yl)propyl)-2-(2-(methylsulfonyl)phenoxy)acetamide 
• 1616059-81-4 ethyl 2-(2-(methylsulfonyl)phenoxy)acetate 
• 1374405-45-4 2-(methylsulfonyl)phenyl benzoate 
• 950649-13-5 4-(2-methanesulfonylphenyloxy)piperidine hydrochloride 
• 950649-12-4 4-(2-methanesulfonyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 1146970-01-5 C₂₃H₂₉NO₆S 
• 69181-50-6 α-(t-butylaminomethyl)-4-hydroxy-3-methylsulfonyl benzyl alcohol 
• 56490-75-6 4-benzyloxy-α-bromo-3-methylsulfonylacetophenone 

Relevant articles and documents

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Direct Conversion of Haloarenes to Phenols under Mild, Transition-Metal-Free Conditions

A high-yielding and practical method for the synthesis of phenols from electron-deficient haloarenes and heteroarenes has been developed. The products are formed from acetohydroxamic acid as the hydroxide source via a novel SNAr reaction/Lossen rearrangement sequence. Notably, these reactions employ inexpensive and air-stable reagents, require no special handling, occur under mildly basic conditions, and form products in high yields in the presence of electrophilic and protic functionality. The utility of this methodology is demonstrated by the high-yielding hydroxylation of two base-sensitive complex substrates.

PYRROLIDINE-2-CARBONITRILE DERIVATIVES AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV)

The present invention relates to compounds of formula (I), (I), which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, syndrome X, hyperinsulinemia, b-cell failure, obesity, satiety disorders, atherosclerosis, and various immunomodulatory diseases.