114719-65-2

Usage

Chemical compound

Benzenemethanethiol, 2,4-dimethoxy-

Upstream product

• 7314-44-5 2,4-dimethoxylbenzyl alcohol 

Downstream Products

• 181823-88-1 2-(2,4-Dimethoxy-benzylsulfanyl)-6-phenyl-nicotinic acid 
• 181823-86-9 2-[(2,4-dimethoxybenzyl)thio]-6-methylpyridine-3-carboxylic acid 
• 1025973-66-3 2-(2,4-Dimethoxy-benzylsulfanyl)-6-isopropyl-N-pyridin-4-yl-nicotinamide 
• 1027202-62-5 2-(2,4-Dimethoxy-benzylsulfanyl)-6-isobutyl-N-pyridin-4-yl-nicotinamide 
• 850465-57-5 (+/-)-1-[2-(2,4-dimethoxyphenylmethanesulfonylmethyl)-phenyl]-ethanol 
• 850465-58-6 (2,4-dimethoxy)-phenylmethanesulfonylmethyl-(2-nitro)-phenyl 
• 950857-41-7 C₂₄H₂₂F₃NO₅S 

Relevant academic research and scientific papers

Direct synthesis of di- and trimethoxybenzyl thiols from the corresponding alcohol

An efficient and reliable procedure for the one-pot synthesis of di- and trimethoxybenzyl thiols from the corresponding benzyl alcohol is described.

Nicotinamide derivatives as a new class of gastric (H+/K+)-ATPase inhibitors. II. Synthesis and structure-activity relationships of 2-[(2,4- dimethoxyhenzyl)sulfinyl]-N-(4-pyridinyl)pyridine-3-carboxamides

Members of a new series of 2-[(2,4-dimethoxybenzyl)sulfinyl]-N-(4- pyridinyl)pyridine-3-carboxamides were synthesized and evaluated for their gastric antisecretory activity and the ability to inhibit cytochrome P450- dependent O-dealkylation of 7-ethoxycoumarin (7-EC) in rat liver microsomes. Several of the compounds synthesized exhibited potent inhibitory activities against both [14C]aminopyrine accumulation stimulated by dibutyryl cyclic AMP in isolated rabbit parietal cells and histamine-induced gastric acid secretion in pylorus-ligated rats when administered intraduodenally; their inhibitory activities were equivalent to or superior to those of the parent compound [2[(2,4-dimethoxybenzyl)sulfinyl]-N-(4-pyridinyl)pyridine-3- carboxamide] and omeprazole. Among the compounds having potent antisecretory activity in vitro and in vivo, 2-[(2,4-dimethoxybenzyl)sulfinyl]-N-(2,5- dimethyl-4-pyridinyl)pyridine-3-carboxamide and 2-[(2,4- dimethoxybenzyl)sulfinyl]-N-(2,6-dimethyl-4-pyridinyl)pyridine-3-carboxamide in particular showed lower inhibitory activity against the 7-EC deethylase than omeprazole. It seems probable that, unlike omeprazole, these compounds do not interact with a metabolism of other drugs in vivo. These compounds, therefore, are considered to be more promising candidate agents for treating acid-related gastrointestinal disorders than the parent compound reported previously.