114746-70-2

Basic information

• Product Name: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,(4R)-(9CI)
• Synonyms: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,(4R)-(9CI);(R)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid, (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid, (R)-2,3-O-isopropilidinopropionic acid, 2,3-O-isopropylidene-D-glyceric acid, 2,3-O-isopropylidene-glyceric acid, (R)-glyceric acid acetonide, (R)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid;1,3-Dioxolane-4-carboxylicacid, 2,2-dimethyl-, (4R)-
• CAS NO: 114746-70-2
• Molecular Formula: C₆H₁₀O₄
• Molecular Weight: 146.14
• Product Categories: CARBOXYLICACID
• Mol File: 114746-70-2.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,(4R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,(4R)-(9CI)(114746-70-2)
• EPA Substance Registry System: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,(4R)-(9CI)(114746-70-2)

Safety Data

• Hazardous Substances Data: 114746-70-2(Hazardous Substances Data)

Usage

General Description

1,3-Dioxolane-4-carboxylic acid, 2,2-dimethyl-, (4R)-(9CI) is a chemical compound that belongs to the carboxylic acid group. It is a cyclic organic compound with a dioxolane ring and a carboxylic acid functional group. The chemical is also known as (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid. It is used in various industrial applications, including as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. The compound is usually handled under strict safety regulations due to its potential health and environmental hazards.

Upstream product

• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 55032-17-2 (4R)-4-benzyloxycarbonyl-2,2-dimethyl-1,3-dioxolane 
• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 52373-72-5 methyl (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 60456-21-5 methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 
• 14028-61-6 potassium (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 

Downstream Products

• 148065-34-3 (R)-2,2-dimethyl-1,3-dioxolane-4-carboxamide 

Relevant articles and documents

ARYLMETHYLENE HETEROCYCLIC COMPOUNDS AS KV1.3 POTASSIUM SHAKER CHANNEL BLOCKERS

A compound of Formula (I) or a pharmaceutically acceptable salt thereof is described, wherein the substituents are as defined herein. Pharmaceutical compositions comprising the same and method of using the same are also described.

Electrochemical Oxidation of Alcohols and Aldehydes to Carboxylic Acids Catalyzed by 4-Acetamido-TEMPO: An Alternative to "anelli" and "pinnick" Oxidations

An electrocatalytic method has been developed to oxidize primary alcohols and aldehydes to the corresponding carboxylic acids using 4-acetamido-2,2,6,6-tetramethylpiperidin-1-oxyl (ACT) as a mediator. The method successfully converts benzylic, aliphatic, heterocyclic, and other heteroatom-containing substrates to the corresponding carboxylic acids in aqueous solution at room temperature. The mild conditions enable retention of stereochemistry adjacent to the site of oxidation, as demonstrated in a 40 g-scale synthesis of a precursor to levetiracetam, a medication used to treat epilepsy.

Degradation of 1-deoxy-d-erythro-hexo-2,3-diulose in the presence of lysine leads to formation of carboxylic acid amides

A novel species of amides formed from degradation of one of the most important key intermediates in Maillard hexose chemistry-1-deoxyhexo-2,3- diulose-was investigated. In 1-deoxyhexo-2,3-diulose/Nα-t-BOC- lysine reaction mixtures four amides, Nε-acetyl lysine, N ε-formyl lysine, Nε-lactoyl lysine and N ε-glycerinyl lysine, were identified and their structures verified by authentic reference standards. Amides and corresponding carboxylic acids (acetic acid, formic acid, lactic acid and glyceric acid) accumulated over time. Both Nε-lysine amides and carboxylic acids were thus determined as stable Maillard end products. Results of model incubations suggested the synthesis of amides to be mechanistically closely related to the formation of their corresponding carboxylic acids by β-dicarbonyl cleavage. Due to the different chemical properties of all the compounds monitored, various analytical strategies had to be carried out (LC-MS2, GC-MS, GC-FID, enzymatic determination).