114746-84-8

Upstream product

• 135793-87-2 2-(Bromomethyl)-3-phenyl-2-propenoic acid 
• 7042-33-3 ethyl (E)-2-methyl-3-phenyl-2-propenoate 
• 88039-49-0 (Z)-ethyl 2-(bromomethyl)-3-phenylacrylate 
• 100-52-7 benzaldehyde 
• 105479-98-9 ethyl 2-(acetoxy(phenyl)methyl)acrylate 
• 37442-45-8 ethyl 2-(hydroxy(phenyl)methyl)propenoate 

Downstream Products

• 945013-12-7 C₁₈H₁₅ClN₂O₄S 
• 889854-02-8 6-benzyl-4-(4-chlorobenzenesulfonyl)-1,4-diazepan-2,5-dione 

Relevant academic research and scientific papers

Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors

A novel series of 6-substituted 4-sulfonyl-1,4-diazepane-2,5-diones were designed, synthesized and evaluated as human chymase inhibitors. Structure-activity relationship studies led to the identification of a potent inhibitor, (6S)-6-(5-chloro-2-methoxybe

NOVEL PHENYLALANINE ANALOGUES AS PUTATIVE INHIBITORS OF ENZYMES ACTING ON PHENALALANINE

Two analogues of phenylalanine, (+/-)-2-aminomethyl-3-phenylpropanoic acid and (E)-2-aminomethyl-3-phenylpropenoic acid, were synthesized and found to inhibit buckwheat phenylalanine ammonia-lyase (PAL) competitively with Ki values of 16.5 and