1147552-88-2

Basic information

• Product Name: C₂₂H₂₄FN₅O₃S
• CAS NO: 1147552-88-2
• Molecular Weight: 457.529
• Mol File: 1147552-88-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₄FN₅O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₄FN₅O₃S(1147552-88-2)
• EPA Substance Registry System: C₂₂H₂₄FN₅O₃S(1147552-88-2)

Safety Data

• Hazardous Substances Data: 1147552-88-2(Hazardous Substances Data)

Upstream product

• 185099-67-6 N-Boc-nortropinone 
• 194222-05-4 (1R,3R,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 4316-97-6 4,6-dichloro-5-methylpyrimidine 
• 937734-25-3 tert-butyl (1R,3s,5S)-3-[(4-nitrobenzoyl)oxy]-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 1147557-54-7 C₁₇H₂₄ClN₃O₃ 
• 1147557-61-6 C₁₂H₁₆ClN₃O 
• 1147557-62-7 C₁₅H₂₀ClN₃O₃S 
• 61272-77-3 2-cyano-4-fluoroaniline 
• 143557-91-9 (1R,3S,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 

Relevant articles and documents

Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes

The lead optimization studies of a series of GPR119 agonists incorporating a nortropanol scaffold are described. Extensive structure-activity relationship (SAR) studies of the lead compound 20f led to the identification of compound 36j as a potent, single digit nanomolar GPR119 agonist with high agonist activity. Compound 36j was orally active in lowering blood glucose levels in a mouse oral glucose tolerance test and increased plasma insulin levels in a rat hyperglycemic model. It showed good to excellent pharmacokinetic properties in rats and monkeys and no untoward activities in counter-screen assays. Compound 36j demonstrated an attractive in vitro and in vivo profile for further development.