61272-77-3

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C7H5FN2/c8-6-1-2-7(10)5(3-6)4-9/h1-3H,10H2

Upstream product

• 61272-76-2 4-fluoro-2-iodoaniline 
• 50594-78-0 5-fluoro-2-nitrobenzonitrile 
• 2106-02-7 2-chloro-4-fluoroaniline 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 756839-23-3 2-Azido-5-fluorobenzonitrile 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 77206-97-4 2-nitro-5-fluorobenzamide 
• 2646-90-4 2,5-difluorobenzaldehyde 
• 64248-64-2 2,5-difluorobenzonitrile 

Downstream Products

• 1146412-06-7 methyl N-{2-[(2-cyano-4-fluorophenyl)amino]ethyl}-N-{[(1,1-dimethylethyl)oxy]carbonyl}glycinate 
• 1224888-08-7 2-[(2,5-dichloro-4-pyridinyl)amino]-5-fluorobenzonitrile 
• 134517-57-0 2,4-dichloro-6-fluoro-quinazoline 
• 1600526-90-6 2,2'-(triazene-1,3-diyl)-bis(5-fluorobenzonitrile) 
• 362-46-9 5-fluoro-2-aminobenzophenone 
• 380638-36-8 7-fluoro-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one 
• 63069-49-8 2-amino-5-fluorobenzamide 
• 771572-99-7 2-(aminomethyl)-4-fluoroaniline 

Relevant academic research and scientific papers

Preparation method 2 -amino -5 -fluorobenzonitrile

The invention discloses a preparation method of 2 - amino -5 - fluorobenzonitrile, which comprises the specific steps of (1) taking 2, 5 - difluorobenzaldehyde as a starting raw material, condensation reaction with hydroxylamine hydrochloride under the conditions of triethylamine, and generating compound III. (2) Compound III is dehydrated with phosphorus oxychloride to form compound IV. (3) Compound IV is decomposed by ammonia to form compound I. That is 2 - amino -5 - fluorobenzonitrile. The preparation method is higher in yield.

Highly chemoselective reduction of azides to amines by Fe(0) nanoparticles in water at room temperature

A highly chemoselective reduction of aryl, heteroaryl, acyl and sulfonyl azides to the corresponding amines has been achieved by Fe(0) nanoparticles in water at room temperature in the absence of external hydride source. Several readily reducible functionalities including alkene, alkyne, S-S linkage, OTBDMS remain unaffected during reduction.

A Homogeneous Method for the Conveniently Scalable Palladium- and Nickel-Catalyzed Cyanation of Aryl Halides

Homogeneous conditions for the palladium-catalyzed cyanation of aryl halides were developed. This new system features a broad scope of aryl chlorides and bromides, uses 2-propanol or 1-butanol as solvent, and is readily scalable. The same conditions can also provide simple benzonitriles using the recently developed (TMEDA)NiCl(o-tolyl) precatalyst in conjunction with 1,1′-bis(diphenylphosphino)ferrocene (dppf) as a ligand.

BENZOTRIAZEPINONE DERIVATIVES

The present invention is concerned with benzotriazepinone derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-l or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.

3-Aminoindazole derivatives

.Iadd.Pharmaceutical compositions having muscle relaxant and analgesic activity containing 3-aminoindazoles..Iaddend.