1147553-27-2Relevant academic research and scientific papers
Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active GPR119 agonists
Dai, Xing,Stamford, Andrew,Liu, Hong,Neustadt, Bernard,Hao, Jingsong,Kowalski, Tim,Hawes, Brian,Xu, Xiaoying,Baker, Hana,O'Neill, Kim,Woods, Morgan,Tang, Huadong,Greenlee, William
, p. 5291 - 5294 (2015/11/09)
The design and synthesis of two conformationally restricted oxazabicyclo octane derivatives as GRP119 agonists is described. Derivatives of scaffold C, with syn configuration, have the best overall profiles with respect to solubility and in vivo efficacy. Compound 25a was found to have extremely potent agonistic activity and was orally active in lowering blood glucose levels in a mouse oral glucose tolerance test at a dose of 0.1 mg/kg.
BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF
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Page/Page column 188, (2009/05/30)
The present invention relates to Bicyclic Heterocycle Derivatives, compositions comprising a Bicyclic Heterocycle Derivative, and methods of using the Bicyclic Heterocycle Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.
