114763-29-0Relevant articles and documents
Medium-scale preparation of useful metabolites of aromatic compounds via whole-cell fermentation with recombinant organisms
Endoma, Mary Ann,Bui, Vu P.,Hansen, Jeff,Hudlicky, Tomas
, p. 525 - 532 (2013/09/06)
The whole-cell fermentation of aromatic coumpounds with Escherichia coli JM109 (pDTG601) on a medium scale (10-15L) produces enantiopure cyclohexadienediols. A detailed procedure for the fermentation is described, and yields for several metabolites are provided. A similar procedure using E. coli JM109 (pDTG602) affords catechols. The dienediols are useful for asymmetric synthesis, and several important targets originating from these metabolites are tabulated.
Enzymatic and Chemical Syntheses of cis-Dihydrodiol Derivatives of Monocyclic Arenes
Boyd, Derek R.,Hand, Mark V.,Sharma, Narain D.,Chima, Jagdeep,Dalton, Howard,Sheldrake, Gary N.
, p. 1630 - 1632 (2007/10/02)
Metabolism of bromobenzene and iodobenzene by growing cultures of Pseudomonas putida UV4 gave the corresponding cis-dihydrodiol products 1 and 2 in high yields; subsequent direct chemical substitution of the halogen atoms in these metabolites provided a new range of enantiomerically pure cis-dihydrodiols of known absolute configuration.